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STX1A and PSMA3
Number of citations of the paper that reports this interaction (PubMedID
24722188
)
69
Data Source:
BioGRID
(two hybrid)
STX1A
PSMA3
Description
syntaxin 1A
proteasome 20S subunit alpha 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytosol
Plasma Membrane
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Endomembrane System
Membrane
Secretory Granule
Axon
Synaptic Vesicle Membrane
SNARE Complex
Cytoplasmic Vesicle
Nuclear Membrane
Protein-containing Complex
Actomyosin
Presynaptic Membrane
Neuron Projection
Synapse
Presynaptic Active Zone Membrane
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Schaffer Collateral - CA1 Synapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Molecular Function
SNARE Binding
SNAP Receptor Activity
Protein Binding
Myosin Binding
Calcium Channel Inhibitor Activity
Chloride Channel Inhibitor Activity
Kinase Binding
Protein-macromolecule Adaptor Activity
Myosin Head/neck Binding
Identical Protein Binding
ATP-dependent Protein Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Calcium-dependent Protein Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Positive Regulation Of Neurotransmitter Secretion
Neurotransmitter Transport
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Response To Gravity
Positive Regulation Of Norepinephrine Secretion
Regulation Of Synaptic Vesicle Priming
Synaptic Vesicle Exocytosis
Synaptic Vesicle Docking
Vesicle-mediated Transport
Protein Sumoylation
Calcium-ion Regulated Exocytosis
Regulation Of Exocytosis
Insulin Secretion
Secretion By Cell
Positive Regulation Of Catecholamine Secretion
SNARE Complex Assembly
Regulated Exocytosis
Positive Regulation Of Exocytosis
Positive Regulation Of Calcium Ion-dependent Exocytosis
Hormone Secretion
Vesicle Docking
Synaptic Vesicle Endocytosis
Regulation Of Insulin Secretion
Protein Localization To Membrane
Modulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Excitatory Postsynaptic Potential
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Pathways
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Insulin processing
Regulation of insulin secretion
Other interleukin signaling
Toxicity of botulinum toxin type C (botC)
LGI-ADAM interactions
Neurexins and neuroligins
GABA synthesis, release, reuptake and degradation
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Sensory processing of sound by inner hair cells of the cochlea
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Diseases
GWAS
Hip circumference adjusted for BMI (
34021172
)
Malaria (
31844061
)
Triglyceride levels (
32203549
)
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
169 interacting genes:
AARD
ABCC9
ABI3
AGTRAP
AIG1
ANKRD46
AOC3
APBA1
APOL2
APOL3
AQP3
ARL13B
ARLN
ATP4B
ATP6V1B1
BET1
BLOC1S6
BNIP1
BTN2A2
C1GALT1
CACNA1D
CCSER2
CD81
CDC37
CDK5
CFTR
CLEC1A
CLN6
CMTM7
CPLX1
CSNK2A1
CSNK2A2
CXCL16
CYB5B
DAPK1
DDX49
DSCR9
DYRK1A
EBAG9
EMD
ERG28
ETNK2
FAM3C
GIMAP1
GIMAP5
GOLM2
GOSR2
GPM6B
HMOX1
JAGN1
KCNB1
KIFC3
MAL
MALL
MIP
MMGT1
NAPA
NAPB
NINJ2
NKG7
NRM
NSF
PGAP2
PLN
PLP1
PLPP4
PLPP6
PNLIPRP1
PSMA3
RAB27A
RAB3IL1
RIMS1
RMDN2
RNF4
RTP2
SCNN1A
SCNN1B
SCNN1G
SDCBP
SEC22A
SEC22B
SEPTIN2
SEPTIN5
SERP1
SERP2
SLC6A1
SLC6A2
SLC6A3
SLC6A4
SLC6A5
SLC6A9
SMIM1
SMIM3
SNAP23
SNAP25
SNAP29
SNAP47
SNORC
SNPH
STRIT1
STX10
STX11
STX12
STX16
STX2
STX3
STX4
STX5
STX6
STX7
STX8
STXBP1
STXBP2
STXBP5
STXBP6
SUMO1P1
SYT1
SYT4
SYT7
SYTL4
TCEANC
TMEM100
TMEM120A
TMEM128
TMEM14C
TMEM222
TMEM254
TMEM41A
TMEM60
TNF
TRAF3IP3
TRDMT1
TSGA10IP
TSNARE1
TXLNA
TXLNB
UBE2I
UBTFL1
UNC13B
UPK1B
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP5
VAMP7
VAMP8
VAPB
VIM
VMA12
VPS11
VPS16
VPS18
VSTM4
VTI1B
ZFPL1
ZNF12
ZNF136
ZNF250
ZNF440
ZNF441
ZNF479
ZNF490
ZNF557
ZNF696
ZNF707
ZNF785
ZNF835
120 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
CCDC69
CCL28
CDK6
CDKN1A
CEBPA
CIP2A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FNDC3B
FOS
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
ILF3
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LINC02913
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OLIG2
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TP53
TRIB3
UBD
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
Entrez ID
6804
5684
HPRD ID
01721
01463
Ensembl ID
ENSG00000106089
ENSG00000100567
Uniprot IDs
A0A0C4DFZ1
A8MZ54
Q16623
Q75ME0
A0A140VK43
P25788
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7E55
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
?
SNAP Receptor Activity
SNARE Complex
Membrane Fusion
Organelle Localization By Membrane Tethering
Organelle Membrane Fusion
Syntaxin Binding
Vesicle Fusion
Membrane Docking
Vesicle Docking
Organelle Fusion
SNARE Binding
Vesicle Organization
Membrane Organization
Vesicle-mediated Transport
Exocytosis
Secretion By Cell
Membrane
Syntaxin-1 Binding
Secretion
Establishment Of Localization In Cell
Establishment Of Protein Localization
Organelle Localization
Protein Transport
Regulation Of Exocytosis
Vesicle Docking Involved In Exocytosis
Endomembrane System
Cellular Localization
Intracellular Protein Localization
SNARE Complex Assembly
Neurotransmitter Transport
Positive Regulation Of Exocytosis
Regulated Exocytosis
Regulation Of Secretion By Cell
Calcium-ion Regulated Exocytosis
Synaptic Vesicle Priming
Regulation Of Regulated Secretory Pathway
Regulation Of Secretion
Intracellular Protein Transport
Intracellular Transport
Golgi Vesicle Transport
Signal Release
Synaptic Vesicle Exocytosis
Positive Regulation Of Regulated Secretory Pathway
Regulation Of Vesicle-mediated Transport
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Vesicle Fusion To Plasma Membrane
Presynapse
Regulation Of Transport
Vesicle-mediated Transport In Synapse
Chloride Channel Inhibitor Activity
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Response To Gamma Radiation
Proteasome Complex
Cellular Response To Gamma Radiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Response To Ionizing Radiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Gravity
Cellular Response To Ionizing Radiation
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Molecular Function Activator Activity
Macromolecule Catabolic Process
Negative Regulation Of Cell Cycle
Nuclear Matrix
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Protein Destabilization
Regulation Of Protein Stability
HMG Box Domain Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Hormone Metabolic Process
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
SNAP Receptor Activity
Proteasomal Protein Catabolic Process
Cellular Response To Actinomycin D
Promoter-specific Chromatin Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Senescence
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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