STX1A and SUMO1P1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		STX1A	SUMO1P1
Description		syntaxin 1A	SUMO1 pseudogene 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Membrane Secretory Granule Axon Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Actomyosin Presynaptic Membrane Neuron Projection Synapse Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus PML Body
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein-macromolecule Adaptor Activity Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Calcium-dependent Protein Binding	Protein Binding Transcription Factor Binding Protein Tag Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Protein Sumoylation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Hormone Secretion Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Excitatory Postsynaptic Potential	Protein Sumoylation PML Body Organization
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Triglyceride levels ( 32203549)	Copper levels ( 26025379) Cortical volume ( 32963231) Polycystic ovary syndrome ( 22885925)
Interacting Genes		169 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ARLN ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 DSCR9 DYRK1A EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VMA12 VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835	33 interacting genes: ACTN3 ARK2N AXIN1 CKS1B EDARADD ESRRG FAM118B FAM200A FHL2 FKBP6 GMCL1 HNRNPC KRTAP9-2 L3MBTL3 LCE2A LCE2D MAPK1IP1L NAB2 PHC1 PIAS1 PIAS2 SATB1 SETBP1 SOX5 STX1A SUMO1 TRAF2 TRIM23 UBA2 UBE2I ZBTB26 ZBTB6 ZNRD2
Entrez ID		6804	391257
HPRD ID		01721
Ensembl ID		ENSG00000106089
Uniprot IDs		A0A0C4DFZ1 A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Membrane Fusion Organelle Localization By Membrane Tethering Organelle Membrane Fusion Syntaxin Binding Vesicle Fusion Membrane Docking Vesicle Docking Organelle Fusion SNARE Binding Vesicle Organization Membrane Organization Vesicle-mediated Transport Exocytosis Secretion By Cell Membrane Syntaxin-1 Binding Secretion Establishment Of Localization In Cell Establishment Of Protein Localization Organelle Localization Protein Transport Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Endomembrane System Cellular Localization Intracellular Protein Localization SNARE Complex Assembly Neurotransmitter Transport Positive Regulation Of Exocytosis Regulated Exocytosis Regulation Of Secretion By Cell Calcium-ion Regulated Exocytosis Synaptic Vesicle Priming Regulation Of Regulated Secretory Pathway Regulation Of Secretion Intracellular Protein Transport Intracellular Transport Golgi Vesicle Transport Signal Release Synaptic Vesicle Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Presynapse Regulation Of Transport Vesicle-mediated Transport In Synapse Chloride Channel Inhibitor Activity	Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Small Protein Activating Enzyme Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Factor Binding SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Post-translational Protein Modification Presynaptic Cytosol Postsynaptic Cytosol Transcription Corepressor Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Ubiquitin Protein Ligase Binding SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nuclear Body Negative Regulation Of Calcium-mediated Signaling Chromatin Organization Regulation Of Protein Sumoylation Enzyme Binding Synaptonemal Complex Positive Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
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