STX1A and KCNB1

Number of citations of the paper that reports this interaction (PMID 12403834)
13

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		STX1A	KCNB1
Gene Name		syntaxin 1A (brain)	potassium channel, voltage gated Shab related subfamily B, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Dendrite Dendrite Membrane Neuronal Cell Body Membrane Postsynaptic Membrane
	Molecular Function	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein N-terminus Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Energy Reserve Metabolic Process Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18	14 interactors: KCNB2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A
Entrez ID		6804	3745
HPRD ID		01721	08983
Ensembl ID		ENSG00000106089
Uniprot IDs		A8MZ54 Q16623 Q75ME0	Q14721
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport	Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Ion Transport Metal Ion Transport Protein Complex Assembly Protein Oligomerization Cation Transport Ion Transmembrane Transport Cation Transmembrane Transport Signaling Cell Communication Transmembrane Transport Cellular Component Assembly Transport Energy Reserve Metabolic Process Regulation Of Protein Secretion Regulation Of Protein Localization Regulation Of Caveolin-mediated Endocytosis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Synaptic Vesicle Docking Regulation Of Hormone Secretion Regulation Of Cellular Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Secretion Regulation Of Establishment Of Protein Localization Regulation Of Cellular Process Generation Of Precursor Metabolites And Energy Glutamate Secretion Regulation Of Membrane Depolarization Vesicle Fusion Synaptic Vesicle Exocytosis Regulation Of Membrane Potential Regulation Of Cell Junction Assembly Acid Secretion Vesicle Docking Involved In Exocytosis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Organelle Fusion Regulation Of Cellular Response To Insulin Stimulus Vesicle Docking Dicarboxylic Acid Transport
Tagcloud ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence	3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore
Tagcloud (Difference) ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence	3xtg abundantly accordingly alanine argues c113s c73a caenorhabditis channels ectopic elegans exacerbated homolog insults invertebrate kv2 kvs mimics mutating neuropathy neuroprotective oligomerization oligomers oxidant oxidation oxidizing potassium protected underscore
Tagcloud (Intersection) ?