STX1A and SLC6A5

Number of citations of the paper that reports this interaction (PubMedID 10722844)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		STX1A	SLC6A5
Description		syntaxin 1A	solute carrier family 6 member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Membrane Secretory Granule Axon Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Actomyosin Presynaptic Membrane Neuron Projection Synapse Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Endosome Plasma Membrane Membrane Dense Core Granule Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein-macromolecule Adaptor Activity Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Calcium-dependent Protein Binding	Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Protein Sumoylation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Hormone Secretion Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Excitatory Postsynaptic Potential	Neurotransmitter Transport Chemical Synaptic Transmission Sodium Ion Transmembrane Transport Synaptic Transmission, Glycinergic Glycine Import Across Plasma Membrane
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea	SLC-mediated transport of neurotransmitters Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Drugs
Diseases			Hyperekplexia
GWAS		Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Triglyceride levels ( 32203549)	Carotid intima media thickness (maximum) ( 31801372) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)
Interacting Genes		169 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ARLN ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 DSCR9 DYRK1A EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VMA12 VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835	3 interacting genes: LNX1 SDCBP STX1A
Entrez ID		6804	9152
HPRD ID		01721	08378
Ensembl ID		ENSG00000106089	ENSG00000165970
Uniprot IDs		A0A0C4DFZ1 A8MZ54 Q16623 Q75ME0	Q4VAM4 Q4VAM6 Q9Y345
PDB IDs
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Membrane Fusion Organelle Localization By Membrane Tethering Organelle Membrane Fusion Syntaxin Binding Vesicle Fusion Membrane Docking Vesicle Docking Organelle Fusion SNARE Binding Vesicle Organization Membrane Organization Vesicle-mediated Transport Exocytosis Secretion By Cell Membrane Syntaxin-1 Binding Secretion Establishment Of Localization In Cell Establishment Of Protein Localization Organelle Localization Protein Transport Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Endomembrane System Cellular Localization Intracellular Protein Localization SNARE Complex Assembly Neurotransmitter Transport Positive Regulation Of Exocytosis Regulated Exocytosis Regulation Of Secretion By Cell Calcium-ion Regulated Exocytosis Synaptic Vesicle Priming Regulation Of Regulated Secretory Pathway Regulation Of Secretion Intracellular Protein Transport Intracellular Transport Golgi Vesicle Transport Signal Release Synaptic Vesicle Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Presynapse Regulation Of Transport Vesicle-mediated Transport In Synapse Chloride Channel Inhibitor Activity	Regulation Of Exocytosis Interleukin-5 Receptor Binding Positive Regulation Of Exocytosis Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Nuclear Membrane Syndecan Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Myosin Head/neck Binding Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Extracellular Exosome Assembly Identical Protein Binding ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Substrate-dependent Cell Migration, Cell Extension Actomyosin Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Localization Within Membrane Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Regulation Of Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Channel Inhibitor Activity Synapse Maturation Regulation Of Secretion By Cell Regulation Of Exosomal Secretion Positive Regulation Of Neurotransmitter Secretion Cytoskeletal Anchor Activity Regulation Of Secretion Myosin Binding Protein Modification By Small Protein Conjugation Presynaptic Active Zone Membrane Positive Regulation Of Transport Frizzled Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Calcium-ion Regulated Exocytosis Post-translational Protein Modification Vesicle Docking Involved In Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Catecholamine Secretion
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