SPATA18 and DRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPATA18	DRC4
Description		spermatogenesis associated 18	dynein regulatory complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Intracellular Membrane-bounded Organelle Intracellular Membraneless Organelle	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Molecular Condensate Scaffold Activity Cardiolipin Binding	Protein Binding Microtubule Binding Small GTPase Binding
	Biological Process	CDP-diacylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Mitochondrial Protein Catabolic Process Mitophagy By Internal Vacuole Formation Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process	Microtubule Cytoskeleton Organization Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Brain Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Motility Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Positive Regulation Of Protein Localization To Cilium
Pathways			Activation of SMO
Drugs
Diseases
GWAS		Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Platelet count ( 29403010) Type 2 diabetes ( 30054458) Uterine fibroids ( 30194396)
Interacting Genes		13 interacting genes: AIMP2 CARD10 CCDC102B DRC4 EFHC2 GOLGA2 HOXA1 LRIF1 MAD1L1 PAXIP1 PIBF1 TACC3 TGM7	110 interacting genes: ARL6IP1 BCAR3 BORCS6 BYSL C1orf35 CARD10 CARD9 CBFA2T3 CCDC125 CCDC146 CCDC6 CCHCR1 CCNG1 CDC37 CDR2 CEP70 CFAP53 CINP CKS1B COG6 CPSF7 CRYBB1 CT45A1 CWF19L2 CYSRT1 DAXX DDX17 DISC1 DMAP1 EAF1 EHHADH EIF1AD ERCC1 EVI5L FAM161A FAM161B FHL2 GADD45GIP1 GCC1 GEM GOLGA2 GPRASP3 GRIPAP1 GSTA4 HEXIM2 HOMER3 HOMEZ HOXA1 HSF2BP IGFBP6 KDM1A KRT14 KRT15 KRT16 L3MBTL2 L3MBTL3 LASP1 LHX3 LMO1 LMO2 LZTS1 MAD1L1 MFAP1 MID2 MRFAP1L1 NDOR1 NKAPD1 PLK4 PNKP PNMA5 POLR1C POTEB3 PPFIA1 PRDM14 PRMT5 PRPF18 RALBP1 RBAK RINT1 RUBCN SCNM1 SKIL SORBS3 SP7 SPATA18 SPG21 STAC3 TCEA2 THAP1 TNFAIP3 TRAF2 TRAF5 TRIM41 TRIM54 TSFM TSGA10IP TXLNA TXLNB USHBP1 YES1 YJU2 ZBTB22 ZBTB26 ZBTB39 ZNF212 ZNF250 ZNF572 ZNF620 ZNF629 ZNF792
Entrez ID		132671	2622
HPRD ID		14050	05533
Ensembl ID		ENSG00000163071	ENSG00000141013
Uniprot IDs		A0A140VKF4 Q8TC71	A0A087WZT7 A0A384MR00 B7Z1U9 O95995
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Modification Process Ciliary Basal Body Cytoskeleton Mitotic Spindle Organization Regulation Of Protein Modification Process Mitotic Spindle Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Microtubule-based Process Positive Regulation Of Protein Metabolic Process Spindle Organization Spindle Pole Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Mitotic Spindle Assembly Semicircular Canal Formation MAD1 Complex Abducens Nerve Formation Optokinetic Behavior Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Negative Regulation Of Prostaglandin Biosynthetic Process Microtubule Spindle Assembly Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Chorion Development	Identical Protein Binding Protein Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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