DKK1 and LRP6

Number of citations of the paper that reports this interaction (PMID 11357136)
204

Data Source:
HPRD (in vivo)

		DKK1	LRP6
Gene Name		dickkopf WNT signaling pathway inhibitor 1	low density lipoprotein receptor-related protein 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Receptor Complex Synapse
	Molecular Function	Signal Transducer Activity Protein Binding Growth Factor Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding Kinase Inhibitor Activity Toxin Transporter Activity Apolipoprotein Binding Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Negative Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Complex Assembly Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Skeletal Muscle Tissue Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Cardiac Muscle Cell Differentiation	Gastrulation With Mouth Forming Second Neural Tube Closure Negative Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Pericardium Morphogenesis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Embryonic Pattern Specification Anterior/posterior Pattern Specification Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cerebellum Morphogenesis Thalamus Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Cerebral Cortex Development Regulation Of Ossification Embryonic Limb Morphogenesis Midbrain Development Midbrain-hindbrain Boundary Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis External Genitalia Morphogenesis Post-anal Tail Morphogenesis Cell Migration Involved In Gastrulation Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Bone Resorption Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Folic Acid Palate Development Convergent Extension Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Regulation Of Cell Development Face Morphogenesis Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Trachea Cartilage Morphogenesis Mammary Placode Formation Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Toxin Transport Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)
Protein-Protein Interactions		7 interactors: DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	15 interactors: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 DKK1 DKK2 FZD5 FZD8 GSK3B LRRK2 MESDC1 SERPINF1 WNT1 WNT3A
Entrez ID		22943	4040
HPRD ID		05544	04617
Ensembl ID		ENSG00000107984	ENSG00000070018
Uniprot IDs		I1W660 O94907	F5H7J9 O75581
PDB IDs		3S2K 3S8V	3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Axis Specification Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Axis Specification Dorsal/ventral Pattern Formation Embryonic Retina Morphogenesis In Camera-type Eye Skeletal System Development Cell Migration Involved In Gastrulation Anatomical Structure Regression Ameboidal-type Cell Migration Regulation Of Canonical Wnt Signaling Pathway Bone Development Connective Tissue Development Skeletal System Morphogenesis Wnt Signaling Pathway Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Organ Morphogenesis Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Embryonic Camera-type Eye Development Mammary Gland Duct Morphogenesis Regulation Of Tissue Remodeling Embryonic Digit Morphogenesis Positive Regulation Of Stem Cell Proliferation Pattern Specification Process Embryonic Organ Development Mammary Gland Morphogenesis Midbrain Development Canonical Wnt Signaling Pathway Mammary Gland Epithelium Development Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Regulation Of Stem Cell Proliferation Tissue Remodeling Embryonic Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Bone Morphogenesis Regulation Of Fat Cell Differentiation	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Forebrain Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Segmentation Regulation Of Protein Metabolic Process Cellular Response To Stimulus Generation Of Neurons Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Dermatome Development Spemann Organizer Formation Negative Regulation Of Signal Transduction Neurogenesis Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Neuron Differentiation Negative Regulation Of Signaling Response To Organic Substance Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of Protein Metabolic Process Brain Development Cellular Response To Manganese Ion Chordate Embryonic Development Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching Head Development Multicellular Organismal Development Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Intersection) ?		dkk1