LRP6 and DKK2

Number of citations of the paper that reports this interaction (PubMedID 11357136)
0

Data Source:
HPRD (in vivo)

		LRP6	DKK2
Description		LDL receptor related protein 6	dickkopf Wnt signaling pathway inhibitor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Membrane Raft Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Extracellular Region Extracellular Space
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Wnt Receptor Activity	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Regulation Of DNA-templated Transcription Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Tissue Development Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Vesicle-mediated Transport Midbrain Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Chordate Embryonic Development Response To Peptide Hormone Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Transmembrane Transport Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Cell-cell Adhesion Midbrain Dopaminergic Neuron Differentiation	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)	Blood protein levels ( 30072576) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heel bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 27182965 28196072) Resting-state electroencephalogram vigilance ( 29703947) Telomere length ( 24478790)
Interacting Genes		18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A	2 interacting genes: KRTAP10-6 LRP6
Entrez ID		4040	27123
HPRD ID		04617	05658
Ensembl ID		ENSG00000070018	ENSG00000155011
Uniprot IDs		F5H7J9 O75581	Q9UBU2
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Co-receptor Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Dopaminergic Neuron Differentiation Beta-catenin Destruction Complex Wnt Signalosome Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Signal Transduction Response To Retinoic Acid Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Anatomical Structure Morphogenesis Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Dopaminergic Neuron Differentiation Spemann Organizer Formation Wnt-Frizzled-LRP5/6 Complex Regulation Of Cellular Component Organization Positive Regulation Of Post-translational Protein Modification Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cell Proliferation In Midbrain Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Wnt Signaling Pathway Cellular Response To Oxygen-containing Compound	Wnt Signalosome Wnt-Frizzled-LRP5/6 Complex Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Toxin Transmembrane Transporter Activity Kinase Inhibitor Activity Low-density Lipoprotein Particle Receptor Activity Neural Crest Formation Neural Crest Cell Differentiation Cellular Response To Cholesterol Negative Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Sterol Response To Cholesterol Protein Serine/threonine Kinase Inhibitor Activity Wnt-protein Binding Midbrain Development Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Muscle Cell Apoptotic Process Coreceptor Activity
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