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LRP6 and ANTXR2
Number of citations of the paper that reports this interaction (PMID
16564009
)
36
Data Source:
HPRD
(in vitro, in vivo)
LRP6
ANTXR2
Gene Name
low density lipoprotein receptor-related protein 6
anthrax toxin receptor 2
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Caveola
Cell Surface
Integral Component Of Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Neuronal Cell Body
Receptor Complex
Synapse
Extracellular Region
Endoplasmic Reticulum Membrane
Plasma Membrane
External Side Of Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Molecular Function
Low-density Lipoprotein Receptor Activity
Receptor Binding
Frizzled Binding
Protein Binding
Wnt-protein Binding
Kinase Inhibitor Activity
Toxin Transporter Activity
Apolipoprotein Binding
Identical Protein Binding
Protein Homodimerization Activity
Wnt-activated Receptor Activity
Coreceptor Activity Involved In Wnt Signaling Pathway
Receptor Activity
Protein Binding
Metal Ion Binding
Biological Process
Gastrulation With Mouth Forming Second
Neural Tube Closure
Negative Regulation Of Protein Phosphorylation
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Pericardium Morphogenesis
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Synaptic Transmission
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Neural Crest Formation
Neural Crest Cell Differentiation
Wnt Signaling Pathway
Single Organismal Cell-cell Adhesion
Cerebellum Morphogenesis
Thalamus Development
Cerebral Cortex Cell Migration
Forebrain Radial Glial Cell Differentiation
Wnt Signaling Pathway Involved In Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Regulation Of Ossification
Embryonic Limb Morphogenesis
Midbrain Development
Midbrain-hindbrain Boundary Development
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
External Genitalia Morphogenesis
Post-anal Tail Morphogenesis
Cell Migration Involved In Gastrulation
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Response To Peptide Hormone
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Ossification
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Bone Remodeling
Embryonic Camera-type Eye Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Folic Acid
Palate Development
Convergent Extension
Embryonic Retina Morphogenesis In Camera-type Eye
Canonical Wnt Signaling Pathway
Regulation Of Cell Development
Face Morphogenesis
Bone Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Trachea Cartilage Morphogenesis
Mammary Placode Formation
Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Cellular Response To Cholesterol
Dopaminergic Neuron Differentiation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Primitive Streak Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport
Wnt Signaling Pathway Involved In Somitogenesis
Axis Elongation Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Toxin Transport
Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathogenesis
Reproductive Process
Toxin Transport
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation
negative regulation of TCF-dependent signaling by WNT ligand antagonists
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Ankylosing spondylitis (
21743469
20062062
)
Protein-Protein Interactions
15 interactors:
ANTXR1
ANTXR2
APOB
ATP13A2
AXIN1
DKK1
DKK2
FZD5
FZD8
GSK3B
LRRK2
MESDC1
SERPINF1
WNT1
WNT3A
8 interactors:
COL4A2
COL4A3
COL4A4
COL4A5
LAMB1
LAMC1
LRP6
SMAD2
Entrez ID
4040
118429
HPRD ID
04617
07452
Ensembl ID
ENSG00000070018
ENSG00000163297
Uniprot IDs
F5H7J9
O75581
J3KPY9
P58335
PDB IDs
3S2K
3S8V
3S8Z
3S94
3SOB
3SOQ
3SOV
4A0P
4DG6
1SHT
1SHU
1T6B
1TZN
Enriched GO Terms of Interacting Partners
?
Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Phosphorylation
Nervous System Development
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Anatomical Structure Morphogenesis
Forebrain Development
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Anterior/posterior Pattern Specification
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of MAP Kinase Activity
Segmentation
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Generation Of Neurons
Regulation Of Cell Differentiation
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Dermatome Development
Spemann Organizer Formation
Negative Regulation Of Signal Transduction
Neurogenesis
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Neuron Differentiation
Negative Regulation Of Signaling
Response To Organic Substance
Regulation Of Protein Kinase Activity
Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Brain Development
Cellular Response To Manganese Ion
Chordate Embryonic Development
Regulation Of Kinase Activity
Embryo Development Ending In Birth Or Egg Hatching
Head Development
Multicellular Organismal Development
Regulation Of Signal Transduction
Positive Regulation Of Protein Kinase Activity
Extracellular Matrix Disassembly
Cell Morphogenesis Involved In Differentiation
Extracellular Matrix Organization
Extracellular Structure Organization
Axon Guidance
Cell Development
Cell Morphogenesis
Axonogenesis
Collagen Catabolic Process
Neuron Differentiation
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Collagen Metabolic Process
Locomotion
Endoderm Development
Multicellular Organismal Macromolecule Metabolic Process
Neuron Projection Morphogenesis
Multicellular Organismal Metabolic Process
Anatomical Structure Morphogenesis
Movement Of Cell Or Subcellular Component
Generation Of Neurons
Neuron Projection Development
Cell Projection Morphogenesis
Cell Part Morphogenesis
Neurogenesis
Neuron Development
Response To External Stimulus
Cell Differentiation
Gastrulation
Cell Projection Organization
Endoderm Formation
Nervous System Development
System Development
Multicellular Organismal Development
Anatomical Structure Development
Formation Of Primary Germ Layer
Developmental Process
Glomerular Basement Membrane Development
Response To Cholesterol
Dorsal/ventral Axis Specification
Pericardium Development
Embryonic Morphogenesis
Regulation Of Cell Proliferation
Endodermal Cell Differentiation
Tissue Development
Substrate Adhesion-dependent Cell Spreading
Regulation Of Epithelial Cell Proliferation
Kidney Development
Renal System Development
Tagcloud
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp5
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Difference)
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp5
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Intersection)
?