LRP6 and FZD8

LRP6

FZD8

Name LDL receptor related protein 6 frizzled class receptor 8
Structure PDB 3S2K PDB 5UN5
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
GWAS
  • Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 )
  • Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 )
  • Coronary artery calcification ( 23870195 )
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
  • Heel bone mineral density ( 30598549 )
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
  • Tandem gait ( 26219847 )
  • Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 )
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 )
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )
  • Periodontal microbiota ( 22699663 )
  • Protein quantitative trait loci ( 18464913 )
Interacting Genes 18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A 5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID 4040 8325
HPRD ID 04617 05852
Ensembl ID ENSG00000070018 ENSG00000177283
Uniprot IDs F5H7J9 O75581 Q9H461
PDB IDs 3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C 5UN5 5UN6 6NDZ 8X0T
GO Terms Enriched among Interactors