LRP6 and FZD8

Number of citations of the paper that reports this interaction (PMID 11029007)
235

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		LRP6	FZD8
Gene Name		low density lipoprotein receptor-related protein 6	frizzled class receptor 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Receptor Complex Synapse	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Low-density Lipoprotein Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding Kinase Inhibitor Activity Toxin Transporter Activity Apolipoprotein Binding Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway	G-protein Coupled Receptor Activity Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Gastrulation With Mouth Forming Second Neural Tube Closure Negative Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Pericardium Morphogenesis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Embryonic Pattern Specification Anterior/posterior Pattern Specification Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cerebellum Morphogenesis Thalamus Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Cerebral Cortex Development Regulation Of Ossification Embryonic Limb Morphogenesis Midbrain Development Midbrain-hindbrain Boundary Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis External Genitalia Morphogenesis Post-anal Tail Morphogenesis Cell Migration Involved In Gastrulation Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Bone Resorption Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Folic Acid Palate Development Convergent Extension Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Regulation Of Cell Development Face Morphogenesis Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Trachea Cartilage Morphogenesis Mammary Placode Formation Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Toxin Transport Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis G-protein Coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		15 interactors: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 DKK1 DKK2 FZD5 FZD8 GSK3B LRRK2 MESDC1 SERPINF1 WNT1 WNT3A	5 interactors: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		4040	8325
HPRD ID		04617	05852
Ensembl ID		ENSG00000070018	ENSG00000177283
Uniprot IDs		F5H7J9 O75581	Q9H461
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Forebrain Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Segmentation Regulation Of Protein Metabolic Process Cellular Response To Stimulus Generation Of Neurons Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Dermatome Development Spemann Organizer Formation Negative Regulation Of Signal Transduction Neurogenesis Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Neuron Differentiation Negative Regulation Of Signaling Response To Organic Substance Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of Protein Metabolic Process Brain Development Cellular Response To Manganese Ion Chordate Embryonic Development Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching Head Development Multicellular Organismal Development Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity	Wnt Signaling Pathway Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Axis Specification Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fat Cell Differentiation Midbrain-hindbrain Boundary Development Positive Regulation Of Wnt Signaling Pathway Embryonic Retina Morphogenesis In Camera-type Eye Cell Migration Involved In Gastrulation Rostrocaudal Neural Tube Patterning Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Canonical Wnt Signaling Pathway Bone Development Dorsal/ventral Axis Specification Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryonic Organ Morphogenesis Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Signal Transduction Epithelial Tube Morphogenesis Cerebellum Morphogenesis Regulation Of Phosphorylation Hindbrain Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Tube Morphogenesis Negative Regulation Of Fat Cell Differentiation Embryonic Camera-type Eye Development Neural Tube Patterning Forebrain Development Cell Differentiation Response To Peptide Hormone Mammary Gland Duct Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Tissue Remodeling Pattern Specification Process Response To Peptide Embryonic Organ Development Gland Development
Tagcloud ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?