DKK1 and KRTAP10-1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DKK1	KRTAP10-1
Description		dickkopf Wnt signaling pathway inhibitor 1	keratin associated protein 10-1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Heart Induction Heart Valve Development Endocardial Cushion Development Endoderm Development Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Response To Retinoic Acid Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of JNK Cascade Regulation Of Synapse Organization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Limb Development Head Morphogenesis Face Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Motor Learning Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Synapse Pruning Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	Keratinization
Drugs
Diseases
GWAS		Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 21076409 27577874 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	152 interacting genes: ADAMTSL4 AEN AMMECR1 ATP23 AVPI1 BAHD1 BCL6B C17orf50 C22orf39 CAMK1G CARD9 CATSPER1 CBX2 CHIC2 CHRD CLPP CRCT1 CREB5 CTSZ CXCL16 CYSRT1 DAAM2 DEFB112 DHX57 DKK1 DOCK2 ECE1 FAM76B FBXO34 FCHO1 FUCA2 GLRX3 HOXA1 HOXA9 HPCAL1 HSD3B7 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LINGO1 MAPKBP1 MEOX2 MOBP MRPL12 NBPF19 NECTIN2 NKD1 NLK NOTCH2NLA NPDC1 NR1D2 NR4A1 NR4A3 NUFIP2 OTX1 PID1 PIN1 PLLP POM121L8P POU4F2 PPARA PRKAG1 PRM2 PRPF31 RNF8 RSPO2 SH3GLB2 SHFL SLC23A1 SLC6A20 SMCP SPATA24 SPATA3 SPATA8 SPRY1 SPRY2 TNP2 TRIM42 TSPAN4 TULP3 WT1 ZBTB24 ZNF101 ZNF124 ZNF138 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF438 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF625 ZNF664 ZNF768 ZNF785 ZSCAN12 ZSCAN26
Entrez ID		22943	386677
HPRD ID		05544	11184
Ensembl ID		ENSG00000107984	ENSG00000215455
Uniprot IDs		I1W660 O94907	P60331
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE
Enriched GO Terms of Interacting Partners?		Wnt-Frizzled-LRP5/6 Complex Toxin Transmembrane Transporter Activity Wnt Signalosome Wnt Receptor Activity Wnt-protein Binding Wnt Signaling Pathway Coreceptor Activity Glucagon Processing Endocytosis Canonical Wnt Signaling Pathway Cell-cell Signaling Involved In Mammary Gland Development Stem Cell Differentiation	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding DNA Binding Lung Growth Identical Protein Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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