DKK1 and KRTAP10-1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DKK1	KRTAP10-1
Gene Name		dickkopf WNT signaling pathway inhibitor 1	keratin associated protein 10-1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Keratin Filament
	Molecular Function	Signal Transducer Activity Protein Binding Growth Factor Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Negative Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Complex Assembly Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Skeletal Muscle Tissue Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)
Protein-Protein Interactions		7 interactors: DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	73 interactors: ADAMTSL4 AEN AVPI1 BAHD1 BCL6B C19orf66 CARD9 CATSPER1 CBX2 CHIC2 CHRD CREB5 CXCL16 DAAM2 DHX57 DKK1 DOCK2 ECE1 FAM76B GLRX3 HOXA1 HPCAL1 HSD3B7 KRTAP10-3 KRTAP12-1 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E MAPKBP1 MEOX2 MOBP NOTCH2NL NPDC1 NR4A1 OTX1 PID1 PIN1 POM121L8P PRM2 PRPF31 PVRL2 RSPO2 SLC23A1 SLC6A20 SPATA8 SPRY1 SPRY2 TULP3 ZBTB24 ZNF101 ZNF124 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF785 ZSCAN12 ZSCAN26
Entrez ID		22943	386677
HPRD ID		05544	11184
Ensembl ID		ENSG00000107984	ENSG00000215455
Uniprot IDs		I1W660 O94907	P60331
PDB IDs		3S2K 3S8V
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Axis Specification Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Axis Specification Dorsal/ventral Pattern Formation Embryonic Retina Morphogenesis In Camera-type Eye Skeletal System Development Cell Migration Involved In Gastrulation Anatomical Structure Regression Ameboidal-type Cell Migration Regulation Of Canonical Wnt Signaling Pathway Bone Development Connective Tissue Development Skeletal System Morphogenesis Wnt Signaling Pathway Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Organ Morphogenesis Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Embryonic Camera-type Eye Development Mammary Gland Duct Morphogenesis Regulation Of Tissue Remodeling Embryonic Digit Morphogenesis Positive Regulation Of Stem Cell Proliferation Pattern Specification Process Embryonic Organ Development Mammary Gland Morphogenesis Midbrain Development Canonical Wnt Signaling Pathway Mammary Gland Epithelium Development Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Regulation Of Stem Cell Proliferation Tissue Remodeling Embryonic Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Bone Morphogenesis Regulation Of Fat Cell Differentiation	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Biosynthetic Process Lung Growth Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Regulation Of Neurotrophin TRK Receptor Signaling Pathway Limb Development Embryonic Morphogenesis Pattern Specification Process Developmental Process Embryonic Neurocranium Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Epithelium Development Cellular Process Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Multicellular Organismal Development Respiratory Tube Development Anterior/posterior Pattern Specification Organ Development Lung Morphogenesis Respiratory System Development Embryonic Limb Morphogenesis Tissue Development Cell Differentiation Negative Regulation Of Ras GTPase Activity Limb Morphogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Tube Development Embryo Development Branch Elongation Of An Epithelium Inner Ear Morphogenesis
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?