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LRP6 and MESDC1
Number of citations of the paper that reports this interaction (PMID
16989816
)
7
Data Source:
HPRD
(in vivo)
LRP6
MESDC1
Gene Name
low density lipoprotein receptor-related protein 6
mesoderm development candidate 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Caveola
Cell Surface
Integral Component Of Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Neuronal Cell Body
Receptor Complex
Synapse
Molecular Function
Low-density Lipoprotein Receptor Activity
Receptor Binding
Frizzled Binding
Protein Binding
Wnt-protein Binding
Kinase Inhibitor Activity
Toxin Transporter Activity
Apolipoprotein Binding
Identical Protein Binding
Protein Homodimerization Activity
Wnt-activated Receptor Activity
Coreceptor Activity Involved In Wnt Signaling Pathway
Biological Process
Gastrulation With Mouth Forming Second
Neural Tube Closure
Negative Regulation Of Protein Phosphorylation
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Pericardium Morphogenesis
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Synaptic Transmission
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Neural Crest Formation
Neural Crest Cell Differentiation
Wnt Signaling Pathway
Single Organismal Cell-cell Adhesion
Cerebellum Morphogenesis
Thalamus Development
Cerebral Cortex Cell Migration
Forebrain Radial Glial Cell Differentiation
Wnt Signaling Pathway Involved In Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Regulation Of Ossification
Embryonic Limb Morphogenesis
Midbrain Development
Midbrain-hindbrain Boundary Development
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
External Genitalia Morphogenesis
Post-anal Tail Morphogenesis
Cell Migration Involved In Gastrulation
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Response To Peptide Hormone
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Ossification
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Bone Remodeling
Embryonic Camera-type Eye Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Folic Acid
Palate Development
Convergent Extension
Embryonic Retina Morphogenesis In Camera-type Eye
Canonical Wnt Signaling Pathway
Regulation Of Cell Development
Face Morphogenesis
Bone Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Trachea Cartilage Morphogenesis
Mammary Placode Formation
Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Cellular Response To Cholesterol
Dopaminergic Neuron Differentiation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Primitive Streak Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport
Wnt Signaling Pathway Involved In Somitogenesis
Axis Elongation Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Toxin Transport
Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation
negative regulation of TCF-dependent signaling by WNT ligand antagonists
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
ANTXR1
ANTXR2
APOB
ATP13A2
AXIN1
DKK1
DKK2
FZD5
FZD8
GSK3B
LRRK2
MESDC1
SERPINF1
WNT1
WNT3A
1 interactors:
LRP6
Entrez ID
4040
59274
HPRD ID
04617
11300
Ensembl ID
ENSG00000070018
ENSG00000140406
Uniprot IDs
F5H7J9
O75581
Q9H1K6
PDB IDs
3S2K
3S8V
3S8Z
3S94
3SOB
3SOQ
3SOV
4A0P
4DG6
Enriched GO Terms of Interacting Partners
?
Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Phosphorylation
Nervous System Development
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Anatomical Structure Morphogenesis
Forebrain Development
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Anterior/posterior Pattern Specification
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of MAP Kinase Activity
Segmentation
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Generation Of Neurons
Regulation Of Cell Differentiation
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Dermatome Development
Spemann Organizer Formation
Negative Regulation Of Signal Transduction
Neurogenesis
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Neuron Differentiation
Negative Regulation Of Signaling
Response To Organic Substance
Regulation Of Protein Kinase Activity
Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Brain Development
Cellular Response To Manganese Ion
Chordate Embryonic Development
Regulation Of Kinase Activity
Embryo Development Ending In Birth Or Egg Hatching
Head Development
Multicellular Organismal Development
Regulation Of Signal Transduction
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development
Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
External Genitalia Morphogenesis
Wnt Signaling Pathway Involved In Forebrain Neuroblast Division
Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport
Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation
Axis Elongation Involved In Somitogenesis
Neural Crest Formation
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
Pericardium Morphogenesis
Mammary Placode Formation
Forebrain Radial Glial Cell Differentiation
Wnt Signaling Pathway Involved In Somitogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Intracellular Cholesterol Transport
Intracellular Sterol Transport
Trachea Cartilage Morphogenesis
Radial Glial Cell Differentiation
Primitive Streak Formation
Negative Regulation Of Non-canonical Wnt Signaling Pathway
Formation Of Radial Glial Scaffolds
Mammary Gland Formation
Midbrain-hindbrain Boundary Development
Response To Folic Acid
Embryonic Retina Morphogenesis In Camera-type Eye
Regulation Of Smooth Muscle Cell Apoptotic Process
Trachea Cartilage Development
Thalamus Development
Convergent Extension
Forebrain Neuroblast Division
Positive Regulation Of Bone Resorption
Cellular Response To Cholesterol
Cell Migration Involved In Gastrulation
Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Dopaminergic Neuron Differentiation
Trachea Morphogenesis
Cellular Response To Sterol
Genitalia Morphogenesis
Cartilage Morphogenesis
Rostrocaudal Neural Tube Patterning
Tagcloud
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp5
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Difference)
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp5
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Intersection)
?