DKK1 and CKAP4

Number of citations of the paper that reports this interaction (PubMedID 27322059)
53

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		DKK1	CKAP4
Description		dickkopf Wnt signaling pathway inhibitor 1	cytoskeleton associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytoskeleton Plasma Membrane Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Heart Induction Heart Valve Development Endocardial Cushion Development Endoderm Development Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Response To Retinoic Acid Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of JNK Cascade Regulation Of Synapse Organization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Limb Development Head Morphogenesis Face Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Motor Learning Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Synapse Pruning Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 21076409 27577874 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	15 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NEIL3 NKX3-1 OGT PLAT THOC7 TSNAX WASHC3
Entrez ID		22943	10970
HPRD ID		05544	16717
Ensembl ID		ENSG00000107984	ENSG00000136026
Uniprot IDs		I1W660 O94907	Q07065
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE
Enriched GO Terms of Interacting Partners?		Wnt-Frizzled-LRP5/6 Complex Toxin Transmembrane Transporter Activity Wnt Signalosome Wnt Receptor Activity Wnt-protein Binding Wnt Signaling Pathway Coreceptor Activity Glucagon Processing Endocytosis Canonical Wnt Signaling Pathway Cell-cell Signaling Involved In Mammary Gland Development Stem Cell Differentiation
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