DKK1 and MDFI

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		DKK1	MDFI
Gene Name		dickkopf WNT signaling pathway inhibitor 1	MyoD family inhibitor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Nucleus Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Growth Factor Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Negative Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Complex Assembly Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Skeletal Muscle Tissue Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)
Protein-Protein Interactions		7 interactors: DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		22943	4188
HPRD ID		05544	07280
Ensembl ID		ENSG00000107984	ENSG00000112559
Uniprot IDs		I1W660 O94907	B1AKB6 Q99750
PDB IDs		3S2K 3S8V
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Axis Specification Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Axis Specification Dorsal/ventral Pattern Formation Embryonic Retina Morphogenesis In Camera-type Eye Skeletal System Development Cell Migration Involved In Gastrulation Anatomical Structure Regression Ameboidal-type Cell Migration Regulation Of Canonical Wnt Signaling Pathway Bone Development Connective Tissue Development Skeletal System Morphogenesis Wnt Signaling Pathway Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Organ Morphogenesis Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Embryonic Camera-type Eye Development Mammary Gland Duct Morphogenesis Regulation Of Tissue Remodeling Embryonic Digit Morphogenesis Positive Regulation Of Stem Cell Proliferation Pattern Specification Process Embryonic Organ Development Mammary Gland Morphogenesis Midbrain Development Canonical Wnt Signaling Pathway Mammary Gland Epithelium Development Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Regulation Of Stem Cell Proliferation Tissue Remodeling Embryonic Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Bone Morphogenesis Regulation Of Fat Cell Differentiation	Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?