DKK1 and LRP5

Number of citations of the paper that reports this interaction (PMID 11516963)
25

Data Source:
HPRD (in vivo)

		DKK1	LRP5
Gene Name		dickkopf WNT signaling pathway inhibitor 1	low density lipoprotein receptor-related protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Mitochondrion Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Signal Transducer Activity Protein Binding Growth Factor Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transporter Activity Wnt-activated Receptor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Negative Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Complex Assembly Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Skeletal Muscle Tissue Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Cardiac Muscle Cell Differentiation	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Embryonic Limb Morphogenesis Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Regulation Of Bone Remodeling Bone Marrow Development Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Canonical Wnt Signaling Pathway Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)	Bone mineral density ( 18455228 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		7 interactors: DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	8 interactors: AXIN1 CAPRIN2 DKK1 FZD8 MESDC2 SMAD9 THBS1 WNT1
Entrez ID		22943	4041
HPRD ID		05544	04616
Ensembl ID		ENSG00000107984	ENSG00000162337
Uniprot IDs		I1W660 O94907	O75197
PDB IDs		3S2K 3S8V
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Axis Specification Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Axis Specification Dorsal/ventral Pattern Formation Embryonic Retina Morphogenesis In Camera-type Eye Skeletal System Development Cell Migration Involved In Gastrulation Anatomical Structure Regression Ameboidal-type Cell Migration Regulation Of Canonical Wnt Signaling Pathway Bone Development Connective Tissue Development Skeletal System Morphogenesis Wnt Signaling Pathway Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Organ Morphogenesis Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Embryonic Camera-type Eye Development Mammary Gland Duct Morphogenesis Regulation Of Tissue Remodeling Embryonic Digit Morphogenesis Positive Regulation Of Stem Cell Proliferation Pattern Specification Process Embryonic Organ Development Mammary Gland Morphogenesis Midbrain Development Canonical Wnt Signaling Pathway Mammary Gland Epithelium Development Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Regulation Of Stem Cell Proliferation Tissue Remodeling Embryonic Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Bone Morphogenesis Regulation Of Fat Cell Differentiation	Wnt Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Cellular Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Phosphorylation Canonical Wnt Signaling Pathway Anatomical Structure Development Tissue Development Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Mesoderm Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nervous System Development Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Regionalization System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of MAP Kinase Activity Bone Development Regulation Of Signal Transduction Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Brain Development Head Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Intersection) ?		dkk1