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DKK1
Gene Name
dickkopf WNT signaling pathway inhibitor 1
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Early Endosome Membrane
Molecular Function
Signal Transducer Activity
Protein Binding
Growth Factor Activity
Receptor Antagonist Activity
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Morphogenesis Involved In Differentiation
Endoderm Formation
Mesoderm Formation
Hair Follicle Development
Regulation Of Receptor Internalization
Negative Regulation Of Wnt Signaling Pathway
Embryonic Limb Morphogenesis
Negative Regulation Of BMP Signaling Pathway
Forebrain Development
Negative Regulation Of Protein Complex Assembly
Response To Retinoic Acid
Negative Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Mesodermal Cell Fate Specification
Regulation Of Endodermal Cell Fate Specification
Negative Regulation Of Skeletal Muscle Tissue Development
Face Morphogenesis
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway Involved In Somitogenesis
Extracellular Negative Regulation Of Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
negative regulation of TCF-dependent signaling by WNT ligand antagonists
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Electrocardiographic traits (
20062063
)
Ventricular conduction (
21076409
)
Protein-protein Interactions
7 interactors:
DPP4
KREMEN1
KRTAP10-1
LRP5
LRP6
MDFI
SMAD9
Entrez ID
22943
HPRD ID
05544
Ensembl ID
ENSG00000107984
Uniprot IDs
I1W660
O94907
PDB IDs
3S2K
3S8V
Enriched GO Terms of Interacting Partners
?
Dorsal/ventral Axis Specification
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Regulation Of Wnt Signaling Pathway
Axis Specification
Dorsal/ventral Pattern Formation
Embryonic Retina Morphogenesis In Camera-type Eye
Skeletal System Development
Cell Migration Involved In Gastrulation
Anatomical Structure Regression
Ameboidal-type Cell Migration
Regulation Of Canonical Wnt Signaling Pathway
Bone Development
Connective Tissue Development
Skeletal System Morphogenesis
Wnt Signaling Pathway
Embryonic Camera-type Eye Morphogenesis
Positive Regulation Of Mesenchymal Cell Proliferation
Embryonic Organ Morphogenesis
Regulation Of Bone Remodeling
Embryonic Eye Morphogenesis
Regulation Of Mesenchymal Cell Proliferation
Branching Involved In Mammary Gland Duct Morphogenesis
Gastrulation With Mouth Forming Second
Retina Morphogenesis In Camera-type Eye
Bone Remodeling
Embryonic Camera-type Eye Development
Mammary Gland Duct Morphogenesis
Regulation Of Tissue Remodeling
Embryonic Digit Morphogenesis
Positive Regulation Of Stem Cell Proliferation
Pattern Specification Process
Embryonic Organ Development
Mammary Gland Morphogenesis
Midbrain Development
Canonical Wnt Signaling Pathway
Mammary Gland Epithelium Development
Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development
Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Regulation Of Stem Cell Proliferation
Tissue Remodeling
Embryonic Morphogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Bone Morphogenesis
Regulation Of Fat Cell Differentiation
Tagcloud
?
abcb1b
administrated
brosis
colla1
corroborated
dkk2
dkk3
dkk4
fi
frizzled
frzb
fz1
fz5
fz7
nano
nephrotoxicity
osteopontin
sfrp
tio2
wnt1
wnt10a
wnt11
wnt2
wnt3
wnt4
wnt5a
wnt6
wnt7a
wnt9a