DKK1 and KREMEN1

Number of citations of the paper that reports this interaction (PubMedID 12050670)
0

Data Source:
HPRD (in vivo, in vitro)

		DKK1	KREMEN1
Description		dickkopf Wnt signaling pathway inhibitor 1	kringle containing transmembrane protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Heart Induction Heart Valve Development Endocardial Cushion Development Endoderm Development Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Response To Retinoic Acid Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of JNK Cascade Regulation Of Synapse Organization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Limb Development Head Morphogenesis Face Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Motor Learning Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Synapse Pruning Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation	Apoptotic Process Cell Communication Signal Transduction Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Axon Regeneration Limb Development Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 21076409 27577874 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)	Birth weight ( 27680694 31043758) Blood protein levels ( 30072576) Heel bone mineral density ( 28869591 30598549) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Pancreatic cancer ( 25086665) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	1 interacting genes: DKK1
Entrez ID		22943	83999
HPRD ID		05544	11182
Ensembl ID		ENSG00000107984	ENSG00000183762
Uniprot IDs		I1W660 O94907	Q96MU8
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE	5FWS 5FWT 5FWU 5FWV 5FWW 7BZT 7BZU
Enriched GO Terms of Interacting Partners?		Wnt-Frizzled-LRP5/6 Complex Toxin Transmembrane Transporter Activity Wnt Signalosome Wnt Receptor Activity Wnt-protein Binding Wnt Signaling Pathway Coreceptor Activity Glucagon Processing Endocytosis Canonical Wnt Signaling Pathway Cell-cell Signaling Involved In Mammary Gland Development Stem Cell Differentiation	Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Mesodermal Cell Fate Specification Positive Regulation Of Dopaminergic Neuron Differentiation Regulation Of Endodermal Cell Fate Specification Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Mesodermal Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Heart Induction Head Morphogenesis Negative Regulation Of Synapse Assembly Regulation Of Heart Morphogenesis Motor Learning Synapse Pruning Negative Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Fate Commitment Receptor Antagonist Activity Co-receptor Binding Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Cardiocyte Differentiation Endocardial Cushion Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Endoderm Formation Negative Regulation Of Synapse Organization Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Differentiation Heart Valve Development Regulation Of Presynapse Assembly Low-density Lipoprotein Particle Receptor Binding Organ Induction Regulation Of Presynapse Organization Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Animal Organ Formation Negative Regulation Of SMAD Protein Signal Transduction Developmental Induction Face Morphogenesis Endoderm Development Negative Regulation Of Striated Muscle Cell Differentiation Hair Follicle Development Negative Regulation Of Ossification Regulation Of Cell Fate Commitment Mesoderm Formation Limb Development Mesenchyme Development Formation Of Primary Germ Layer Negative Regulation Of BMP Signaling Pathway
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