LRP6 and SERPINF1

Number of citations of the paper that reports this interaction (PubMedID 21576363)
83

Data Source:
BioGRID (pull down)

		LRP6	SERPINF1
Description		LDL receptor related protein 6	serpin family F member 1
Image
GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Membrane Raft Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Extracellular Region Basement Membrane Extracellular Space Axon Extracellular Matrix Melanosome Neuronal Cell Body Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Wnt Receptor Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Tissue Development Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Vesicle-mediated Transport Midbrain Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Chordate Embryonic Development Response To Peptide Hormone Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Transmembrane Transport Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Cell-cell Adhesion Midbrain Dopaminergic Neuron Differentiation	Kidney Development Short-term Memory Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Response To Peptide
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs			Copper
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)	Blood protein levels ( 30072576) Calcium levels ( 20705733)
Interacting Genes		18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A	11 interacting genes: CSNK2A1 EPM2AIP1 IMPACT KDR LRP6 MLH1 MYOC NEDD4L PNPLA2 PTPN11 SGTB
Entrez ID		4040	5176
HPRD ID		04617	01408
Ensembl ID		ENSG00000070018	ENSG00000132386
Uniprot IDs		F5H7J9 O75581	A0A140VKF3 P36955
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C	1IMV
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Co-receptor Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Dopaminergic Neuron Differentiation Beta-catenin Destruction Complex Wnt Signalosome Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Signal Transduction Response To Retinoic Acid Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Anatomical Structure Morphogenesis Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Dopaminergic Neuron Differentiation Spemann Organizer Formation Wnt-Frizzled-LRP5/6 Complex Regulation Of Cellular Component Organization Positive Regulation Of Post-translational Protein Modification Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cell Proliferation In Midbrain Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Wnt Signaling Pathway Cellular Response To Oxygen-containing Compound	Regulation Of Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Membrane Depolarization Wnt Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Biological Quality Positive Regulation Of Catabolic Process Hsp90 Protein Binding Coreceptor Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Cellular Developmental Process Regulation Of Mitochondrial Depolarization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Focal Adhesion Assembly Frizzled Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Skeletal Muscle Hypertrophy Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Triglyceride Metabolic Process Regulation Of Cytoplasmic Translational Initiation In Response To Stress Receptor Tyrosine Kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Cell-substrate Junction Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma ERBB Signaling Pathway Neutral Lipid Metabolic Process Acylglycerol Metabolic Process Intestinal Epithelial Cell Migration TRC Complex Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Cellular Response To Hydrogen Sulfide Cell Differentiation Male Meiosis Chromosome Segregation MutLalpha Complex Cerebellar Cortex Formation
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