CD93 and COL4A1

Number of citations of the paper that reports this interaction (PubMedID 1377218)
0

Data Source:
HPRD (in vitro)

		CD93	COL4A1
Description		CD93 molecule	collagen type IV alpha 1 chain
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Cytoplasmic Vesicle Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Phagocytosis Cell Adhesion Macrophage Activation Cell-cell Adhesion	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Neutrophil degranulation	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases			Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly
GWAS		Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)	Age-related nuclear cataracts ( 24951543) Arterial stiffness ( 20031579) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 31959993 29785010) Lateral ventricle volume ( 31530798) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Myocardial infarction ( 33532862 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Peripheral artery disease ( 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Stroke ( 30383316) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		25 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 ITGB1 KIR2DL2 KNG1 MBL2 MMRN2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2	30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1
Entrez ID		22918	1282
HPRD ID		00396	00359
Ensembl ID		ENSG00000125810	ENSG00000187498
Uniprot IDs		Q9NPY3	A5PKV2 P02462
PDB IDs		8A59 8IVD	1LI1 5NAX 5NAY 6MPX
Enriched GO Terms of Interacting Partners?		Collagen Trimer Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Platelet-derived Growth Factor Binding Response To Amino Acid Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Amino Acid Stimulus Signal Transduction Signaling Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fibrillar Collagen Trimer Inflammatory Response Glomerular Basement Membrane Development Molecular Adaptor Activity Skin Morphogenesis Regulation Of Proteolysis Endothelial Cell Migration Misfolded Protein Binding Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Symbiont Cell Surface Protease Binding Cell Migration Involved In Sprouting Angiogenesis Regulation Of ERAD Pathway Killing Of Cells Of Another Organism Angiogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Killing By Host Of Symbiont Cells Leukocyte Activation Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Cellular Response To Vitamin E Protein Heterotrimerization Neuromuscular Junction Development Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Wound Healing Zymogen Activation Cellular Response To Lipoprotein Particle Stimulus	Extracellular Region Extracellular Matrix Basement Membrane Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Binding Acute-phase Response Extracellular Exosome Cell Adhesion Endoplasmic Reticulum Lumen Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis High-density Lipoprotein Particle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycosaminoglycan Binding Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Regulation Of Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Developmental Process Endodermal Cell Differentiation Calcium Ion Binding Golgi Lumen Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Proteoglycan Binding Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neurogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Inflammatory Response Negative Regulation Of Platelet Activation Regulation Of Wound Healing Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Laminin Binding Negative Regulation Of Wound Healing Bone Development Positive Regulation Of Nervous System Development
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