CD93 and COL4A3

Number of citations of the paper that reports this interaction (PubMedID 1377218)
0

Data Source:
HPRD (in vitro)

		CD93	COL4A3
Description		CD93 molecule	collagen type IV alpha 3 chain
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Cytoplasmic Vesicle Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Angiogenesis Phagocytosis Cell Adhesion Macrophage Activation Cell-cell Adhesion	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Neutrophil degranulation	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)	Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 29760442 31798171 32528159) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Interacting Genes		25 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 ITGB1 KIR2DL2 KNG1 MBL2 MMRN2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		22918	1285
HPRD ID		00396	00354
Ensembl ID		ENSG00000125810	ENSG00000169031
Uniprot IDs		Q9NPY3	Q01955
PDB IDs		8A59 8IVD	5NB0 6WKU
Enriched GO Terms of Interacting Partners?		Collagen Trimer Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Platelet-derived Growth Factor Binding Response To Amino Acid Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Amino Acid Stimulus Signal Transduction Signaling Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fibrillar Collagen Trimer Inflammatory Response Glomerular Basement Membrane Development Molecular Adaptor Activity Skin Morphogenesis Regulation Of Proteolysis Endothelial Cell Migration Misfolded Protein Binding Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Symbiont Cell Surface Protease Binding Cell Migration Involved In Sprouting Angiogenesis Regulation Of ERAD Pathway Killing Of Cells Of Another Organism Angiogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Killing By Host Of Symbiont Cells Leukocyte Activation Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Cellular Response To Vitamin E Protein Heterotrimerization Neuromuscular Junction Development Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Wound Healing Zymogen Activation Cellular Response To Lipoprotein Particle Stimulus	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion
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