PDLIM3 and ACTN2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDLIM3	ACTN2
Gene Name		PDZ and LIM domain 3	actinin, alpha 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Z Disc	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Structural Constituent Of Muscle	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Actin Filament Organization Heart Development	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways			Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ABCA1 ACTN2	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		27295	88
HPRD ID		08388	00019
Ensembl ID			ENSG00000077522
Uniprot IDs		Q53GG5	B2RCS5 P35609 Q59FD9
PDB IDs			1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Interleukin-1 Beta Secretion Apolipoprotein A-I-mediated Signaling Pathway Microspike Assembly Interleukin-1 Secretion Secretion By Cell Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Negative Regulation Of Protein Localization To Cell Surface Secretion Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Platelet Dense Granule Organization Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Phospholipid Efflux Phagocytosis, Engulfment Positive Regulation Of Transport Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Positive Regulation Of Potassium Ion Transmembrane Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Regulation Of Protein Localization To Cell Surface Positive Regulation Of Cholesterol Transport Negative Regulation Of Potassium Ion Transport Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Cdc42 Protein Signal Transduction Muscle Filament Sliding Actin-myosin Filament Sliding Focal Adhesion Assembly Cytokine Secretion Response To Fluid Shear Stress Regulation Of Cholesterol Transport Regulation Of Potassium Ion Transmembrane Transport Secretory Granule Organization Negative Regulation Of Transporter Activity	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		anxa1 b6d2f1 bladder ccnb2 cnn1 concordant datasets dysregulated fischer fm05 itih5 kif20a krt14 krt18 ldha ldhb lgals4 mining myh11 myl9 overlapped pcp4 permit rodent rodents rrm2 serpina1 suitability t0p2a	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		anxa1 b6d2f1 bladder ccnb2 cnn1 concordant datasets dysregulated fischer fm05 itih5 kif20a krt14 krt18 ldha ldhb lgals4 mining myh11 myl9 overlapped pcp4 permit rodent rodents rrm2 serpina1 suitability t0p2a	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?