KIAA1377 and MRPS6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KIAA1377	MRPS6
Gene Name		KIAA1377	mitochondrial ribosomal protein S6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Midbody Ciliary Base	Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Small Ribosomal Subunit
	Molecular Function	Protein Binding	Structural Constituent Of Ribosome Protein Binding Small Ribosomal Subunit RRNA Binding
	Biological Process	Mitotic Spindle Organization Cytoplasmic Microtubule Organization Cilium Assembly	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways			Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		86 interactors: AIMP2 AKTIP ARIH2 ATP6V1F ATRX BMI1 BRD1 C11orf58 CDKN2B CRCT1 CSTF2 DGCR6 DISC1 DLEU1 DNM1 DUSP12 DUSP23 EIF2S2 EIF6 EPN1 FAM118B FAM134A FEZ1 FGFR3 FXR1 GEMIN7 GET4 GIT1 GOLGB1 GPRASP2 GSTO1 HMOX2 HTT ING5 KAT5 KAT7 KIF15 KLHL20 LAMTOR5 LPL LRRC1 LUC7L2 MAD2L1BP MAPK9 MRPS6 NAP1L5 NAT9 NPM3 NSF NUDT21 ODF2L OFD1 PBK PDCD5 PFDN1 PIK3R3 PMF1 POLD1 POLR2M PPP1CA PPP1CC PRKRA PTPRS RAB27A RAN RBM23 RGS2 RIF1 ROGDI RPA2 RUVBL1 SAT1 SNRPG SPDL1 STAU2 TFG TNFRSF14 TNFSF11 TOMM20 TTR TXNDC9 VIM YAE1D1 YWHAZ ZBED8 ZNF24	8 interactors: APP KIAA1377 LRIF1 MKRN3 RNF181 SREBF2 SRPK2 STAT5A
Entrez ID		57562	64968
HPRD ID		17212	11374
Ensembl ID		ENSG00000110318	ENSG00000243927
Uniprot IDs		Q9P2H0	P82932
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Mitotic Cell Cycle Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Process Response To Light Stimulus Response To Radiation Triglyceride Catabolic Process Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Organelle Localization Acylglycerol Catabolic Process Endomembrane System Organization Establishment Of Organelle Localization Cell Cycle Process Positive Regulation Of Signal Transduction Peptidyl-lysine Modification Endosome Organization Protein Localization To Organelle Positive Regulation Of Metabolic Process Anatomical Structure Development System Development Regulation Of Signal Transduction Termination Of RNA Polymerase II Transcription Cytoplasmic Transport Programmed Cell Death Chromosome Organization Cell Division Ribosomal Subunit Export From Nucleus Cell Death Regulation Of Signaling Cellular Response To Stimulus Death Histone H3 Acetylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Response To Abiotic Stimulus Positive Regulation Of Striated Muscle Contraction Cellular Response To Organic Substance RNA Metabolic Process Organ Development Neurotransmitter Uptake	Positive Regulation Of Cell Cycle Positive Regulation Of Mast Cell Differentiation Nuclear Speck Organization Regulation Of Multicellular Organism Growth Cholesterol Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Positive Regulation Of Gene Expression Negative Regulation Of Mast Cell Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Creatinine Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Mast Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Mast Cell Proliferation Isoleucine Metabolic Process Axon Choice Point Recognition Allantoin Metabolic Process Gene Expression Cellular Response To Laminar Fluid Shear Stress Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Cell Cycle Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Activation Neuron Remodeling Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Cholesterol Transport Succinate Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Developmental Growth Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Response To Low-density Lipoprotein Particle Positive Regulation Of Interleukin-2 Biosynthetic Process
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