GTF3C1 and IGFBP3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GTF3C1	IGFBP3
Description		general transcription factor IIIC subunit 1	insulin like growth factor binding protein 3
Image
GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Nucleolus Membrane Ribonucleoprotein Complex	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter RRNA Transcription TRNA Transcription 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III	MAPK Cascade Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation
Drugs			Alitretinoin Mecasermin
Diseases
GWAS		Asthma ( 31959851) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494)	Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 23696881 30072576) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418 28498854 27841878) FEV1 ( 30804560) Height ( 33713608 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 30487518 29403010 28739976 28498854 28135244 27841878 27618448) QRS duration ( 21076409 27577874) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618448 27618447) Tonsillectomy ( 28928442 27182965) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		25 interacting genes: AGTRAP AKTIP ASCC2 CHN1 CMTM5 CPE CSNK1E DEDD EZH2 FGFR3 GTF3C4 HGH1 IGFBP3 KLF6 MAGEA4 MAPK10 PRPF38A RBM23 SNU13 SUMO2 SUPT5H TBC1D17 UBC UBE3A WEE2-AS1	38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF
Entrez ID		2975	3486
HPRD ID		07540	00899
Ensembl ID		ENSG00000077235	ENSG00000146674
Uniprot IDs		Q12789	B3KPF0 P17936
PDB IDs		8CLI 8CLJ 8CLK 8CLL	7WRQ
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm	Extracellular Region Peptidase Activity Endopeptidase Activity Serine-type Endopeptidase Activity Extracellular Matrix Extracellular Space Cell Surface Receptor Signaling Pathway Response To UV-A Proteolysis Positive Regulation Of Signal Transduction Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Stress Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Collagen Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To UV-A Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Apoptotic Process Response To UV Regulation Of Cell Population Proliferation Extracellular Matrix Organization Extracellular Structure Organization Biological Process Involved In Interaction With Symbiont Regulation Of Epithelial Cell Proliferation Positive Regulation Of Multicellular Organismal Process Cellular Response To UV Regulation Of Signal Transduction Metalloendopeptidase Activity Collagen Catabolic Process Regulation Of Programmed Cell Death Chemical Homeostasis Gland Development Homeostatic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Cellular Response To Light Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Developmental Process Response To Radiation Hydrolase Activity Glucose Homeostasis
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