FER and CTTN

Number of citations of the paper that reports this interaction (PMID 9748248)
71

Data Source:
HPRD (in vitro, in vivo)

		FER	CTTN
Gene Name		fer (fps/fes related) tyrosine kinase	cortactin
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Microtubule Cytoskeleton Lamellipodium Cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone
	Molecular Function	Actin Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Rab GTPase Binding Protein Kinase Binding Gamma-catenin Binding Cadherin Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Mast Cell Degranulation Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by SCF-KIT
Drugs
Diseases
GWAS		Adiponectin levels ( 21700879) Height ( 20881960)
Protein-Protein Interactions		14 interactors: CALM1 CDH1 CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP STAT3 TMF1 YWHAB	36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1
Entrez ID		2241	2017
HPRD ID		01491	01268
Ensembl ID			ENSG00000085733
Uniprot IDs		P16591 Q05DA5	Q14247 Q53HG7
PDB IDs		2KK6	1X69 2D1X
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway Defense Response ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Adherens Junction Organization Cellular Response To Indole-3-methanol Developmental Process System Development Fc-epsilon Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Multicellular Organismal Development Positive Regulation Of Transferase Activity Anatomical Structure Development Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Regulation Of Cellular Localization Organ Development Glial Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Cell Surface Receptor Signaling Pathway Cell Junction Assembly Positive Regulation Of Transport Cellular Localization Cell-cell Junction Organization Locomotion Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Response To Stress Gliogenesis Immune Response Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization
Tagcloud ?		amongst ark axl cdnas compartment compartments consequence contaminated dissect exclusively fresh freshly fyn hemopoietic immortalized mesodermal notion origin preparation ptk repertoire sequenced tec thymic thymocytes thymus tsc tyro ufo	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		amongst ark axl cdnas compartment compartments consequence contaminated dissect exclusively fresh freshly fyn hemopoietic immortalized mesodermal notion origin preparation ptk repertoire sequenced tec thymic thymocytes thymus tsc tyro ufo	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?