FER and TMF1

Number of citations of the paper that reports this interaction (PubMedID 9742951)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FER	TMF1
Description		FER tyrosine kinase	TATA element modulatory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Lamellipodium Cell Junction Protein-containing Complex Cell Projection Anchoring Junction	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Kinase Activity Transferase Activity	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Androgen Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Signal Transduction Tyrosine Phosphorylation Of STAT Protein Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Male Gonad Development Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Involved In Immune Response Adherens Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Interleukin-6-mediated Signaling Pathway Seminiferous Tubule Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Adherens Junction Disassembly Positive Regulation Of Supramolecular Fiber Organization	Acrosome Assembly Positive Regulation Of Cytokine Production Apoptotic Process Spermatid Development Spermatid Nucleus Differentiation Male Gonad Development Negative Regulation Of Gene Expression Flagellated Sperm Motility Androgen Receptor Signaling Pathway Luteinizing Hormone Secretion Leydig Cell Differentiation Defense Response To Bacterium Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Protein Catabolic Process Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Testosterone Secretion
Pathways		Signaling by SCF-KIT	Retrograde transport at the Trans-Golgi-Network
Drugs		Fostamatinib
Diseases
GWAS		Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) White blood cell count ( 32888494)	Meat-related diet ( 32066663) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB	9 interacting genes: AR CMTM5 FER GFI1B ITSN2 KAT2B NR3C1 RAB6A SMARCA4
Entrez ID		2241	7110
HPRD ID		01491	03081
Ensembl ID		ENSG00000151422	ENSG00000144747
Uniprot IDs		P16591 Q6PEJ9	P82094 Q6PII6
PDB IDs		2KK6 6KC4
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol ErbB-3 Class Receptor Binding Cell Motility Response To Indole-3-methanol Catenin Complex Cadherin Binding Phosphotyrosine Residue Binding Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Cell Migration Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus ERBB3:ERBB2 Complex Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling ERBB Signaling Pathway Regulation Of Angiogenesis Regulation Of Cellular Localization Regulation Of Vasculature Development ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Catenin-TCF7L2 Complex Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Localization To Nucleus Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Signaling Receptor Binding Glial Cell Differentiation Negative Regulation Of Programmed Cell Death Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Developmental Process Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Regulation Of Multicellular Organismal Process	Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Protein-containing Complex Seminiferous Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Steroid Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nuclear Receptor Activity Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Induction Lipid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Oxygen-containing Compound RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Male Somatic Sex Determination Cellular Response To Hormone Stimulus Regulation Of Developmental Process Adherens Junction Disassembly Nuclear Glucocorticoid Receptor Activity Chromatin Organization Peptidyl-cysteine Methylation Regulation Of Myoblast Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Steroid Hormone Stimulus Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Cell-cell Junction Disassembly Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity Clathrin-dependent Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process
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