FER and CHD1

		FER	CHD1
Description		FER tyrosine kinase	chromodomain helicase DNA binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Lamellipodium Cell Junction Protein-containing Complex Cell Projection Anchoring Junction	Nuclear Chromosome Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Kinase Activity Transferase Activity	Nucleotide Binding DNA Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Histone H3K4me3 Reader Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Signal Transduction Tyrosine Phosphorylation Of STAT Protein Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Male Gonad Development Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Involved In Immune Response Adherens Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Interleukin-6-mediated Signaling Pathway Seminiferous Tubule Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Adherens Junction Disassembly Positive Regulation Of Supramolecular Fiber Organization	Chromatin Organization Chromatin Remodeling Nucleosome Organization Host-mediated Activation Of Viral Transcription
Pathways		Signaling by SCF-KIT	Estrogen-dependent gene expression
Drugs		Fostamatinib
Diseases
GWAS		Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) White blood cell count ( 32888494)	Basophil percentage of white cells ( 27863252) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Periodontitis (Mean PAL) ( 24024966) Renal sinus fat ( 22044751)
Interacting Genes		19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB	9 interacting genes: BCLAF1 H3-3A H3-4 HDAC1 NCOR1 SAFB SPP1 SRSF3 SSRP1
Entrez ID		2241	1105
HPRD ID		01491	03668
Ensembl ID		ENSG00000151422	ENSG00000153922
Uniprot IDs		P16591 Q6PEJ9	A0A087WVF4 B3KT33 O14646
PDB IDs		2KK6 6KC4	2B2T 2B2U 2B2V 2B2W 2B2Y 2N39 4B4C 4NW2 4O42 5AFW 8UMG
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol ErbB-3 Class Receptor Binding Cell Motility Response To Indole-3-methanol Catenin Complex Cadherin Binding Phosphotyrosine Residue Binding Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Cell Migration Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus ERBB3:ERBB2 Complex Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling ERBB Signaling Pathway Regulation Of Angiogenesis Regulation Of Cellular Localization Regulation Of Vasculature Development ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Catenin-TCF7L2 Complex Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Localization To Nucleus Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Signaling Receptor Binding Glial Cell Differentiation Negative Regulation Of Programmed Cell Death Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Developmental Process Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Regulation Of Multicellular Organismal Process	Regulation Of Androgen Receptor Signaling Pathway Chromatin Organization Response To Macrophage Colony-stimulating Factor Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosome Assembly DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Nucleosome Organization RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Platelet-derived Growth Factor Protein-DNA Complex Assembly Response To Peptide Response To Cytokine Nucleoplasm Nucleosomal DNA Binding Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone Deacetylase Complex Embryo Implantation Chromatin Remodeling Heterochromatin Constitutive Heterochromatin Formation Adherens Junction Disassembly Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Transcription Repressor Complex Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Cell-cell Junction Disassembly Structural Constituent Of Chromatin Krueppel-associated Box Domain Binding Protein-RNA Sequence-specific Adaptor Activity Positive Regulation Of Estradiol Secretion Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Kit Signaling Pathway Protein Lysine Delactylase Activity Fungiform Papilla Formation Cellular Response To Leukemia Inhibitory Factor Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion Male Gonad Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Tyrosine Phosphorylation Of STAT Protein Regulation Of Macromolecule Metabolic Process Extracellular Matrix-cell Signaling Chromatin Gonad Development Nucleosome
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