FER and YWHAB

Number of citations of the paper that reports this interaction (PubMedID 15324660)
0

Data Source:
HPRD (in vivo)

		FER	YWHAB
Description		FER tyrosine kinase	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Lamellipodium Cell Junction Protein-containing Complex Cell Projection Anchoring Junction	Nucleus Cytoplasm Vacuole Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Protein-containing Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Kinase Activity Transferase Activity	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Signal Transduction Tyrosine Phosphorylation Of STAT Protein Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Male Gonad Development Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Involved In Immune Response Adherens Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Interleukin-6-mediated Signaling Pathway Seminiferous Tubule Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Adherens Junction Disassembly Positive Regulation Of Supramolecular Fiber Organization	Protein Targeting Signal Transduction Intracellular Protein Localization Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by SCF-KIT	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Fostamatinib	Copper Phenethyl Isothiocyanate
Diseases
GWAS		Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) White blood cell count ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)
Interacting Genes		19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB	147 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FILNC1 FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B NCAM2 NEDD4L OSBPL3 PARD3 PARD6B PDCL2 PDE3B PDE4B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RIPK2 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		2241	7529
HPRD ID		01491	03184
Ensembl ID		ENSG00000151422	ENSG00000166913
Uniprot IDs		P16591 Q6PEJ9	P31946 V9HWD6
PDB IDs		2KK6 6KC4	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP 8DP5 8EQ8 8EQH
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol ErbB-3 Class Receptor Binding Cell Motility Response To Indole-3-methanol Catenin Complex Cadherin Binding Phosphotyrosine Residue Binding Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Cell Migration Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus ERBB3:ERBB2 Complex Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling ERBB Signaling Pathway Regulation Of Angiogenesis Regulation Of Cellular Localization Regulation Of Vasculature Development ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Catenin-TCF7L2 Complex Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Localization To Nucleus Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Signaling Receptor Binding Glial Cell Differentiation Negative Regulation Of Programmed Cell Death Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Developmental Process Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Regulation Of Multicellular Organismal Process	Kinase Activity Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cytosol Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm Protein Phosphorylation ATP Binding Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Signal Transduction Cellular Response To Oxygen-containing Compound Protein Tyrosine Kinase Activity Response To Stress Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Membrane Potential Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Cadherin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Regulation Of Biological Quality Plasma Membrane Response To Insulin Positive Regulation Of Catabolic Process Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Phosphorylation
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