DDIAS and ACTN1

Number of citations of the paper that reports this interaction (PubMedID 28079882)
30

Data Source:
BioGRID (two hybrid)

		DDIAS	ACTN1
Description		DNA damage induced apoptosis suppressor	actinin alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function		Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of DNA Stability Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization
Pathways			Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle
Drugs			Human calcitonin Copper
Diseases
GWAS			Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 29403010 26805783 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)
Interacting Genes		10 interacting genes: ACLY ACTN1 ACTN4 CBY1 ECM1 EFEMP1 FBLN1 MAF1 MIF4GD PLSCR1	93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX
Entrez ID		220042	87
HPRD ID		08062	00020
Ensembl ID		ENSG00000165490	ENSG00000072110
Uniprot IDs		B4DMA1 Q8IXT1	A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814
PDB IDs			2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Calcium Ion Binding Pseudopodium Extracellular Matrix Structural Constituent Regulation Of Macromolecule Biosynthetic Process Integrin Binding Regulation Of Gene Expression Regulation Of Primary Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Macromolecule Metabolic Process ATP Citrate Synthase Activity Extracellular Region Regulation Of DNA-templated Transcription Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of RNA Biosynthetic Process Cortical Actin Cytoskeleton Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion RNA Polymerase III Core Binding Platelet Alpha Granule Lumen Platelet Activation Extracellular Space Regulation Of RNA Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Nucleoside Binding Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Cell Development Positive Regulation Of Sodium:proton Antiporter Activity Stress Fiber Platelet Morphogenesis Structural Constituent Of Postsynapse Extracellular Matrix Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Epidermal Growth Factor Receptor Activity Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone MRNA Stem-loop Binding Complex RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Identical Protein Binding Citrate Metabolic Process Negative Regulation Of Transcription By RNA Polymerase III Z Disc Transmembrane Transporter Binding	Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta
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