DDIAS and ACLY

Number of citations of the paper that reports this interaction (PubMedID 28079882)
30

Data Source:
BioGRID (two hybrid)

		DDIAS	ACLY
Description		DNA damage induced apoptosis suppressor	ATP citrate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Azurophil Granule Lumen Ciliary Basal Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function		Nucleotide Binding Catalytic Activity ATP Citrate Synthase Activity Protein Binding ATP Binding Transferase Activity Metal Ion Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of DNA Stability Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Negative Regulation Of Ferroptosis
Pathways			ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs			Bempedoic acid
Diseases
GWAS			High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		10 interacting genes: ACLY ACTN1 ACTN4 CBY1 ECM1 EFEMP1 FBLN1 MAF1 MIF4GD PLSCR1	10 interacting genes: APP CDKN2A CEBPA DDIAS FXR1 GSK3B HGS KLHL25 PRKACA USP7
Entrez ID		220042	47
HPRD ID		08062	00155
Ensembl ID		ENSG00000165490	ENSG00000131473
Uniprot IDs		B4DMA1 Q8IXT1	P53396
PDB IDs			3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 6Z2H 7LIW 7LJ9 7LLA 7RIG 7RKZ 7RMP 8G1E 8G1F 8G5C 8G5D
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Calcium Ion Binding Pseudopodium Extracellular Matrix Structural Constituent Regulation Of Macromolecule Biosynthetic Process Integrin Binding Regulation Of Gene Expression Regulation Of Primary Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Macromolecule Metabolic Process ATP Citrate Synthase Activity Extracellular Region Regulation Of DNA-templated Transcription Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of RNA Biosynthetic Process Cortical Actin Cytoskeleton Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion RNA Polymerase III Core Binding Platelet Alpha Granule Lumen Platelet Activation Extracellular Space Regulation Of RNA Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Nucleoside Binding Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Cell Development Positive Regulation Of Sodium:proton Antiporter Activity Stress Fiber Platelet Morphogenesis Structural Constituent Of Postsynapse Extracellular Matrix Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Epidermal Growth Factor Receptor Activity Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone MRNA Stem-loop Binding Complex RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Identical Protein Binding Citrate Metabolic Process Negative Regulation Of Transcription By RNA Polymerase III Z Disc Transmembrane Transporter Binding	Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Regulation Of Long-term Synaptic Potentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Proteasomal Protein Catabolic Process Postsynapse Regulation Of Developmental Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process P53 Binding Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Transport TOR Signaling Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Developmental Process Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Translation Intracellular Signaling Cassette Regulation Of Gene Expression Negative Regulation Of Signaling Positive Regulation Of Cell Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Proteolysis Regulation Of Intracellular Protein Transport
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