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TMEM218 and PCNA
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
TMEM218
PCNA
Gene Name
transmembrane protein 218
proliferating cell nuclear antigen
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Integral Component Of Membrane
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Cytoplasm
Centrosome
Nuclear Replication Fork
PCNA Complex
Extracellular Vesicular Exosome
PCNA-p21 Complex
Molecular Function
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Protein Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Identical Protein Binding
DNA Polymerase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Heart Development
Cell Proliferation
Translesion Synthesis
Epithelial Cell Differentiation
Positive Regulation Of Deoxyribonuclease Activity
Telomere Maintenance Via Semi-conservative Replication
Response To Lipid
Response To Cadmium Ion
Pathways
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
G1/S Transition
Removal of DNA patch containing abasic residue
G1/S-Specific Transcription
Resolution of Abasic Sites (AP sites)
Mitotic G1-G1/S phases
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Chromosome Maintenance
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
G0 and Early G1
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions
3 interactors:
CREB3L1
LDLRAD1
PCNA
116 interactors:
ALDOA
APEX1
APEX2
ATAD5
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
EXO1
FANCD2
FANCL
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HLTF
HUS1
ING1
KCTD13
LDHA
LIG1
MCL1
MLH1
MSH2
MSH3
MSH6
MUTYH
MYBBP1A
PARP1
PARP10
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLL
POLM
PPP1CA
PRKDC
PTMA
RAD18
RAD9A
RBBP8
RFC1
RFC2
RFC3
RFC4
RFC5
RNF8
RPA1
SEC23IP
SETD8
SHPRH
SIVA1
SMARCAD1
SPRTN
SUB1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBE2A
UBE2B
UBE2D3
UHRF2
UNG
USP1
USP2
USP4
WDR48
WRN
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
219854
5111
HPRD ID
19054
01456
Ensembl ID
ENSG00000150433
ENSG00000132646
Uniprot IDs
A2RU14
E9PI23
P12004
PDB IDs
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3P87
3TBL
3VKX
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Deoxyribonuclease Activity
Leading Strand Elongation
Translesion Synthesis
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Postreplication Repair
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Cellular Response To Stress
Positive Regulation Of Nuclease Activity
Response To Cadmium Ion
Mismatch Repair
Base-excision Repair
Regulation Of Bone Mineralization
Regulation Of Transcription From RNA Polymerase II Promoter
Telomere Maintenance
Endoplasmic Reticulum Unfolded Protein Response
Nucleotide-excision Repair
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
DNA-dependent DNA Replication
Cellular Response To Topologically Incorrect Protein
DNA Biosynthetic Process
Regulation Of DNA Replication
Response To Unfolded Protein
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of DNA Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Response To Endoplasmic Reticulum Stress
Regulation Of Ossification
RNA Metabolic Process
DNA Metabolic Process
DNA Repair
Cellular Response To DNA Damage Stimulus
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Response To Stress
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Cycle
DNA Recombination
Cellular Nitrogen Compound Metabolic Process
DNA Replication
Nitrogen Compound Metabolic Process
Cell Cycle Process
Chromosome Organization
Base-excision Repair
Cellular Metabolic Process
Telomere Maintenance Via Semi-conservative Replication
Telomere Maintenance
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Recombination
Nuclear DNA Replication
Mitotic Cell Cycle
Mitotic Recombination
Mismatch Repair
Telomere Maintenance Via Telomere Lengthening
DNA Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
Transcription-coupled Nucleotide-excision Repair
DNA Strand Elongation
Cellular Response To Stimulus
Response To Radiation
Response To Stimulus
Organelle Organization
DNA-dependent DNA Replication
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
Response To UV
Double-strand Break Repair
Nucleotide-excision Repair
Response To Abiotic Stimulus
Catabolic Process
Somatic Diversification Of Immunoglobulins
Somatic Hypermutation Of Immunoglobulin Genes
Negative Regulation Of Cellular Metabolic Process
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle
Response To Light Stimulus
Cellular Macromolecule Catabolic Process
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?