TMEM218 and GJB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM218	GJB4
Description		transmembrane protein 218	gap junction protein beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium Membrane Cell Projection	Nucleoplasm Nucleolus Plasma Membrane Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction
	Molecular Function	Protein Binding	Gap Junction Channel Activity Protein Binding
	Biological Process		Cell Communication Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Gap junction assembly
Drugs
Diseases			Erythrokeratodermia variabilis
GWAS		Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)	Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR	9 interacting genes: ARLN COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A
Entrez ID		219854	127534
HPRD ID		19054	05666
Ensembl ID		ENSG00000150433	ENSG00000189433
Uniprot IDs		A2RU14 E9PI23	Q9NTQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid
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