TMEM218 and VSIR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM218	VSIR
Description		transmembrane protein 218	V-set immunoregulatory receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cilium Membrane Cell Projection	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process		Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR	27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3
Entrez ID		219854	64115
HPRD ID		19054	15160
Ensembl ID		ENSG00000150433	ENSG00000107738
Uniprot IDs		A2RU14 E9PI23	Q9H7M9
PDB IDs			6MVL 6OIL 6U6V 8TBQ
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid	Membrane Positive Regulation Of Neutrophil Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cholesterol Binding Plasma Membrane Regulation Of Wound Healing Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Neutrophil Activation Nucleotide-sugar Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Response To Wounding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Phosphatidate Phosphatase Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Chemokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of MiRNA Transcription Positive Regulation Of Cartilage Development Regulation Of Interleukin-1 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Activin Receptor Signaling Pathway Organophosphate Ester Transport Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Dolichol Kinase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Phospholipid Dephosphorylation UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy
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