FANCA and FANCF

Number of citations of the paper that reports this interaction (PMID 12724401)
98

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		FANCA	FANCF
Gene Name		Fanconi anemia, complementation group A	Fanconi anemia, complementation group F
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Fanconi Anaemia Nuclear Complex	Nucleoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Binding	Molecular_function Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	DNA Repair Protein Complex Assembly Male Meiosis Male Gonad Development Female Gonad Development Regulation Of Cell Proliferation	Ovarian Follicle Development DNA Repair Spermatogenesis Biological_process Protein Ubiquitination
Pathways		Fanconi Anemia pathway	Fanconi Anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		46 interactors: AKT1 ALDOA ATP5B ATR AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	7 interactors: FANCA FANCC FANCE FANCG HES1 MARK3 OLFM2
Entrez ID		2175	2188
HPRD ID		06186	04589
Ensembl ID		ENSG00000187741	ENSG00000183161
Uniprot IDs		H3BSR5 O15360 Q86U55	A3KME0 Q9NPI8
PDB IDs			2IQC
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Complex Assembly Cellular Response To Stress Peptidyl-serine Phosphorylation Metabolic Process Nucleosome Disassembly Response To Stimulus Immune System Process Positive Regulation Of Cellular Metabolic Process Cellular Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Cellular Component Assembly Response To Heat Regulation Of Cellular Process Apoptotic Process Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Innate Immune Response Response To Virus Cell Death Death Reproductive Process Positive Regulation Of Cellular Biosynthetic Process 'de Novo' Posttranslational Protein Folding Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization 'de Novo' Protein Folding Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Chromatin Assembly Or Disassembly DNA Damage Checkpoint Cellular Response To Heat Regulation Of Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Apoptotic Process	DNA Repair Developmental Process Involved In Reproduction Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Reproductive Process Reproductive Structure Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Reproductive System Development Female Gonad Development Development Of Primary Female Sexual Characteristics Cellular Response To Stress Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Gonad Development Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Comma-shaped Body Morphogenesis Development Of Primary Sexual Characteristics Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development Germ Cell Development S-shaped Body Morphogenesis Protein Complex Assembly Reproduction Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Fate Determination Auditory Receptor Cell Fate Commitment Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Astrocyte Differentiation Radial Glial Cell Differentiation
Tagcloud ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	bloom brca1 centrosome circumference connected coregulated coregulation divergent e2f e2f3 exploiting fanca fanconi fluctuations govern id jointly mesh microcephaly networks predisposition rb1 retinoblastoma silico subcellular subnetwork upregulation vital
Tagcloud (Difference) ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	bloom brca1 centrosome circumference connected coregulated coregulation divergent e2f e2f3 exploiting fluctuations govern id jointly mesh microcephaly networks predisposition rb1 retinoblastoma silico subcellular subnetwork upregulation vital
Tagcloud (Intersection) ?		fanca fanconi