FANCA and NAMPT

Number of citations of the paper that reports this interaction (PubMedID 14499622)
0

Data Source:
BioGRID (two hybrid)

		FANCA	NAMPT
Description		FA complementation group A	nicotinamide phosphoribosyltransferase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Matrix Cytosol Nuclear Speck Cell Junction Extracellular Exosome
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway	NADP+ Biosynthetic Process Nicotinamide Metabolic Process Inflammatory Response Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD+ Biosynthetic Process Positive Regulation Of Gene Expression Pyridine Nucleotide Biosynthetic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	BMAL1:CLOCK,NPAS2 activates circadian expression Nicotinate metabolism NPAS4 regulates expression of target genes
Drugs			GMX1777 Daporinad CHS-828
Diseases		Fanconi anemia
GWAS		Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Eosinophilic esophagitis ( 34506852) Grapefruit juice consumption ( 31046077)
Interacting Genes		47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	7 interacting genes: ADORA2A AKT2 FANCA GGT1 OGT TMEM132D USP49
Entrez ID		2175	10135
HPRD ID		06186	09938
Ensembl ID		ENSG00000187741	ENSG00000105835
Uniprot IDs		O15360 Q0VAP4	A0A7P0T941 P43490
PDB IDs		7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC 7ENQ 7PPE 7PPF 7PPG 7PPH 7PPI 8DSC 8DSD 8DSE 8DSH 8DSI 8DSM 8DTJ 8F7L 8IVU 8TM7 8Y55
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus	Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Cell Communication Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Adenosine Receptor Activity Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Translational Initiation Negative Regulation Of Signal Transduction Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Communication Positive Regulation Of Translational Initiation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Response To Insulin Positive Regulation Of Translation Regulation Of Glucose Metabolic Process Response To Hormone Negative Regulation Of Signaling Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Cysteine Biosynthetic Process Leukotriene C4 Gamma-glutamyl Transferase Activity Glutathione Hydrolase Activity Peptide Modification Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Processing Leukotriene D4 Biosynthetic Process Descending Aorta Development Peptidyl-lysine Oxidation Protein-lysine 6-oxidase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ascending Aorta Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?