FANCA and GNB2

Number of citations of the paper that reports this interaction (PubMedID 14499622)
0

Data Source:
BioGRID (two hybrid)

		FANCA	GNB2
Description		FA complementation group A	G protein subunit beta 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding
	Biological Process	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases		Fanconi anemia
GWAS		Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		2175	2783
HPRD ID		06186	11820
Ensembl ID		ENSG00000187741	ENSG00000172354
Uniprot IDs		O15360 Q0VAP4	P62879 Q6FHM2
PDB IDs		7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	9AVL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus	Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process
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