FANCA and DUS4L

Number of citations of the paper that reports this interaction (PubMedID 14499622)
0

Data Source:
BioGRID (two hybrid)

		FANCA	DUS4L
Description		FA complementation group A	dihydrouridine synthase 4 like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Binding	Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding TRNA-dihydrouridine20a Synthase Activity TRNA-dihydrouridine20b Synthase Activity
	Biological Process	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway	TRNA Dihydrouridine Synthesis TRNA Processing
Pathways		Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases		Fanconi anemia
GWAS		Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Coronary artery disease ( 33020668) Osteoarthritis ( 21068099) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	2 interacting genes: CRYAA FANCA
Entrez ID		2175	11062
HPRD ID		06186	17886
Ensembl ID		ENSG00000187741	ENSG00000105865
Uniprot IDs		O15360 Q0VAP4	A4D0R5 O95620
PDB IDs		7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus	Tubulin Complex Assembly Response To UV-A Lens Fiber Cell Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Fanconi Anaemia Nuclear Complex Structural Constituent Of Eye Lens Embryonic Eye Morphogenesis Apoptotic Process Involved In Morphogenesis Protein Refolding Female Gonad Development Apoptotic Process Involved In Development Lens Development In Camera-type Eye Protein-containing Complex Assembly Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Eye Morphogenesis Protein-containing Complex Organization Negative Regulation Of Intracellular Transport Animal Organ Development Male Meiotic Nuclear Division
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