FANCA and ENO1

Number of citations of the paper that reports this interaction (PMID 14499622)
5

Data Source:
BioGRID (two hybrid)

		FANCA	ENO1
Gene Name		Fanconi anemia, complementation group A	enolase 1, (alpha)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Fanconi Anaemia Nuclear Complex	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Membrane M Band Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Phosphopyruvate Hydratase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	DNA Repair Protein Complex Assembly Male Meiosis Male Gonad Development Female Gonad Development Regulation Of Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Transcription, DNA-templated Pathogenesis Response To Virus Negative Regulation Of Cell Growth Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Fanconi Anemia pathway	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		46 interactors: AKT1 ALDOA ATP5B ATR AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	20 interactors: AGTPBP1 AMBP BHLHE40 BRCA1 FANCA FYN GRB2 HDAC1 LIG4 MYOC PCNA PLG SERPING1 SRC SUMO4 TERT TRAPPC2 UPF2 YWHAQ YWHAZ
Entrez ID		2175	2023
HPRD ID		06186	01400
Ensembl ID		ENSG00000187741	ENSG00000074800
Uniprot IDs		H3BSR5 O15360 Q86U55	E2DRY6 P06733
PDB IDs			2PSN 3B97
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Complex Assembly Cellular Response To Stress Peptidyl-serine Phosphorylation Metabolic Process Nucleosome Disassembly Response To Stimulus Immune System Process Positive Regulation Of Cellular Metabolic Process Cellular Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Cellular Component Assembly Response To Heat Regulation Of Cellular Process Apoptotic Process Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Innate Immune Response Response To Virus Cell Death Death Reproductive Process Positive Regulation Of Cellular Biosynthetic Process 'de Novo' Posttranslational Protein Folding Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization 'de Novo' Protein Folding Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Chromatin Assembly Or Disassembly DNA Damage Checkpoint Cellular Response To Heat Regulation Of Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Apoptotic Process	Platelet Activation Blood Coagulation Hemostasis Developmental Process Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Organelle Organization Organ Development Cell Activation Response To Wounding Negative Regulation Of Signal Transduction Multicellular Organismal Development DNA Strand Elongation Negative Regulation Of Signaling Anatomical Structure Development System Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death ERBB Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Cell-substrate Adhesion Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stress Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Signaling DNA Replication Regulation Of Organelle Organization Nucleotide-excision Repair, DNA Gap Filling Regulation Of Mitochondrial Depolarization DNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Adhesion Postreplication Repair Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Tagcloud ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	assigned carrying cell cells chromosome chromosomes electrophoresis enolase equilibrium expression gel gene human hybrids indicated mouse p36 pter reciprocal region results somatic starch tested translocation
Tagcloud (Difference) ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	assigned carrying cell cells chromosome chromosomes electrophoresis enolase equilibrium expression gel gene human hybrids indicated mouse p36 pter reciprocal region results somatic starch tested translocation
Tagcloud (Intersection) ?