F11R and PARD3

Number of citations of the paper that reports this interaction (PubMedID 11447115)
43

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		F11R	PARD3
Description		F11 receptor	par-3 family cell polarity regulator
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Protein-containing Complex Extracellular Exosome Tight Junction Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Regulation Of Cytokine Production System Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Cell Differentiation Epithelial Cell Differentiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Symbiont Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Biological Quality Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Bicellular Tight Junction Assembly	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B	31 interacting genes: ACE2 CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ
Entrez ID		50848	56288
HPRD ID		12038	05994
Ensembl ID		ENSG00000158769	ENSG00000148498
Uniprot IDs		Q6FIB4 Q9Y624	Q8TEW0
PDB IDs		1NBQ 3EOY 3TSZ 4ODB	2KOM
Enriched GO Terms of Interacting Partners?		Localization Within Membrane Plasma Membrane Membrane Cell-cell Junction Organization Establishment Of Protein Localization To Membrane Cell-cell Junction Assembly Cell Junction Assembly Cell Junction Organization Protein Insertion Into ER Membrane Cell Junction Cellular Localization Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Bicellular Tight Junction Tight Junction Assembly Tight Junction Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Membrane Regulation Of Insulin Secretion Protein Insertion Into Membrane Cellular Component Maintenance Establishment Of Protein Localization Establishment Of Endothelial Intestinal Barrier Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Peptide Hormone Secretion Protein Targeting Cell-cell Junction Regulation Of Actin Filament-based Process Cell Adhesion Molecule Binding Cell-cell Junction Maintenance Signaling Receptor Binding Anchoring Junction Intracellular Protein Localization Regulation Of Protein Localization Positive Regulation Of Calcium Ion Import Regulation Of Cell Junction Assembly Regulation Of Hormone Secretion Regulation Of Protein Secretion Glial Cell Migration Apical Junction Complex Regulation Of Actin Filament Organization Negative Regulation Of Protein Catabolic Process Melanocortin Receptor Binding Epithelial Cell Development Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway	Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide
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