F11R and ITGAL

Number of citations of the paper that reports this interaction (PubMedID 11812992)
0

Data Source:
HPRD (two hybrid, in vivo)

		F11R	ITGAL
Description		F11 receptor	integrin subunit alpha L
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Protein-containing Complex Extracellular Exosome Tight Junction Anchoring Junction	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding ICAM-3 Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of Cytokine Production System Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Cell Differentiation Epithelial Cell Differentiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Symbiont Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Biological Quality Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Bicellular Tight Junction Assembly	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Memory T Cell Extravasation T Cell Activation Receptor Clustering Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration
Drugs			Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin Rosuvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Pitavastatin Lifitegrast
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 24556642) Ulcerative colitis ( 23128233 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B	7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		50848	3683
HPRD ID		12038	01079
Ensembl ID		ENSG00000158769	ENSG00000005844
Uniprot IDs		Q6FIB4 Q9Y624	B2RAL6 P20701
PDB IDs		1NBQ 3EOY 3TSZ 4ODB	1CQP 1DGQ 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB 7KC3 7KC5 7KC6
Enriched GO Terms of Interacting Partners?		Localization Within Membrane Plasma Membrane Membrane Cell-cell Junction Organization Establishment Of Protein Localization To Membrane Cell-cell Junction Assembly Cell Junction Assembly Cell Junction Organization Protein Insertion Into ER Membrane Cell Junction Cellular Localization Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Bicellular Tight Junction Tight Junction Assembly Tight Junction Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Membrane Regulation Of Insulin Secretion Protein Insertion Into Membrane Cellular Component Maintenance Establishment Of Protein Localization Establishment Of Endothelial Intestinal Barrier Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Peptide Hormone Secretion Protein Targeting Cell-cell Junction Regulation Of Actin Filament-based Process Cell Adhesion Molecule Binding Cell-cell Junction Maintenance Signaling Receptor Binding Anchoring Junction Intracellular Protein Localization Regulation Of Protein Localization Positive Regulation Of Calcium Ion Import Regulation Of Cell Junction Assembly Regulation Of Hormone Secretion Regulation Of Protein Secretion Glial Cell Migration Apical Junction Complex Regulation Of Actin Filament Organization Negative Regulation Of Protein Catabolic Process Melanocortin Receptor Binding Epithelial Cell Development Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway	Integrin Binding Cell-cell Adhesion T Cell Extravasation Leukocyte Cell-cell Adhesion Cell Adhesion Cellular Extravasation Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Raft Distribution Virus Receptor Activity Positive Regulation Of Intracellular Signal Transduction Mononuclear Cell Migration Regulation Of Leukocyte Mediated Cytotoxicity Phagocytosis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Memory T Cell Extravasation Symbiont Entry Into Host Cell Epithelial Cell Development Membrane Microdomain Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Membrane To Membrane Docking T Cell Antigen Processing And Presentation Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Biological Process Involved In Interaction With Host Plasma Membrane Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of MAPK Cascade DN2 Thymocyte Differentiation Negative Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction LUBAC Complex Apoptotic Nuclear Changes Regulation Of CD40 Signaling Pathway Membrane Raft T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Cell Communication Regulation Of Signal Transduction Receptor-mediated Virion Attachment To Host Cell
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