F11R and CAMLG

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		F11R	CAMLG
Name		F11 receptor	calcium modulating ligand
Structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Protein-containing Complex Extracellular Exosome Tight Junction Anchoring Junction	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Cytokine Production System Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Cell Differentiation Epithelial Cell Differentiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Symbiont Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Biological Quality Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Bicellular Tight Junction Assembly	B Cell Homeostasis Receptor Recycling Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		None	Cyclosporine Voclosporin
GWAS		Inflammatory bowel disease ( 23128233 ) Night sleep phenotypes ( 27126917 )	Height ( 18391951 )
Novel Interactors		1 novel interactors: EVL	1 novel interactors: STT3B
Interacting Genes		30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B	21 interacting genes: ADIPOQ AGR2 BCL2L13 EGFR ETNK1 F11R GET1 HSP90B1 HSPA13 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB TMEM31 TNFRSF13B TXNDC12 VWC2
Entrez ID		50848	819
HPRD ID		12038	03073
Ensembl ID		ENSG00000158769	ENSG00000164615
Uniprot IDs		Q6FIB4 Q9Y624	P49069
PDB IDs		1NBQ 3EOY 3TSZ 4ODB	6SO5 8CR1
GO Terms Enriched among Interactors		Localization Within Membrane Plasma Membrane Membrane Cell-cell Junction Organization Establishment Of Protein Localization To Membrane Cell-cell Junction Assembly Cell Junction Assembly Cell Junction Organization Protein Insertion Into ER Membrane Cell Junction Cellular Localization Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Bicellular Tight Junction Tight Junction Assembly Tight Junction Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Membrane Regulation Of Insulin Secretion Protein Insertion Into Membrane Cellular Component Maintenance Establishment Of Protein Localization Establishment Of Endothelial Intestinal Barrier Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Peptide Hormone Secretion Protein Targeting Cell-cell Junction Regulation Of Actin Filament-based Process Cell Adhesion Molecule Binding Cell-cell Junction Maintenance Signaling Receptor Binding Anchoring Junction Intracellular Protein Localization Regulation Of Protein Localization Positive Regulation Of Calcium Ion Import Regulation Of Cell Junction Assembly Regulation Of Hormone Secretion Regulation Of Protein Secretion Glial Cell Migration Apical Junction Complex Regulation Of Actin Filament Organization Negative Regulation Of Protein Catabolic Process Melanocortin Receptor Binding Epithelial Cell Development Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway	Endoplasmic Reticulum Localization Within Membrane Positive Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Protein Localization To Cell Periphery Digestive Tract Morphogenesis Protein-containing Complex Smooth Endoplasmic Reticulum Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Localization To Membrane