TNFSF11 and UPK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFSF11	UPK2
Description		TNF superfamily member 11	uroplakin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Cell Communication Cell Surface Receptor Signaling Pathway JNK Cascade Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Differentiation Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tooth Eruption Bone Resorption Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Bone Development Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Epithelial Cell Differentiation
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Arthritis (juvenile idiopathic) ( 33106285) Asthma (childhood onset) ( 30929738) Bone mineral density ( 23437003 24249740) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 33547301 29403010) Vitiligo ( 27723757)	Asthma ( 31959851)
Interacting Genes		32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1	36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4
Entrez ID		8600	7379
HPRD ID		04031	10295
Ensembl ID		ENSG00000120659	ENSG00000110375
Uniprot IDs		O14788 Q54A98 Q5T9Y4	O00526
PDB IDs		3URF 5BNQ
Enriched GO Terms of Interacting Partners?		Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Response To Tumor Necrosis Factor Response To Lipid Membrane Protein Proteolysis Endopeptidase Activity Metalloendopeptidase Activity Cellular Response To Tumor Necrosis Factor Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Catalytic Activity Response To UV-A Response To DsRNA Response To Epidermal Growth Factor MAP Kinase Activity Metallopeptidase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Regulation Of Lipid Transport Epidermal Growth Factor Receptor Signaling Pathway Response To Amino Acid Starvation Cytokine-mediated Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Cholesterol Biosynthetic Process Membrane Protein Ectodomain Proteolysis I-kappaB/NF-kappaB Complex Interleukin-34-mediated Signaling Pathway Stress-activated MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Stress Stress-activated Protein Kinase Signaling Cascade Regulation Of Steroid Biosynthetic Process Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Defense Response Protein Metabolic Process Regulation Of Golgi Inheritance Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Cholesterol Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Response To Mechanical Stimulus Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process	Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin
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