TNFSF11 and ZC3HC1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TNFSF11	ZC3HC1
Gene Name		tumor necrosis factor (ligand) superfamily, member 11	zinc finger, C3HC-type containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Integral Component Of Plasma Membrane	Nucleus Nuclear Membrane
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Organ Morphogenesis Cytokine-mediated Signaling Pathway Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Osteoclast Development	Mitotic Nuclear Division Protein Ubiquitination Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 23437003) Cortical thickness ( 22792071) Crohn's disease ( 21102463)	Coronary heart disease ( 21378990)
Protein-Protein Interactions		31 interactors: ADAM17 ADAM19 AKT1 BBS10 DDAH2 EEF1A1 EZH2 FAM213B KHDRBS1 KIAA1377 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1	9 interactors: ALK APP CUL1 MAPK1 MAPK3 PDPK1 TNFSF11 TSC22D1 UBC
Entrez ID		8600	51530
HPRD ID		04031	11390
Ensembl ID		ENSG00000120659	ENSG00000091732
Uniprot IDs		O14788 Q54A98 Q5T9Y4	Q86WB0
PDB IDs		3URF
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Membrane Protein Proteolysis Toll-like Receptor 4 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Bacterium Membrane Protein Intracellular Domain Proteolysis Response To Molecule Of Bacterial Origin Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Transferase Activity Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Lipopolysaccharide Response To Growth Factor Response To Epidermal Growth Factor Fc Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Other Organism Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Cell Death Death Regulation Of Innate Immune Response	Positive Regulation Of Transferase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Process Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Cell Death Phosphorylation Death Intracellular Signal Transduction Regulation Of Golgi Inheritance Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway MAPK Cascade Neurotrophin Signaling Pathway Toll-like Receptor 10 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Caveolin-mediated Endocytosis
Tagcloud ?		actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Difference) ?		actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Intersection) ?