TNFSF11 and ADAM17

Number of citations of the paper that reports this interaction (PMID 10224132)
44

Data Source:
HPRD (in vivo)

		TNFSF11	ADAM17
Gene Name		tumor necrosis factor (ligand) superfamily, member 11	ADAM metallopeptidase domain 17
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding	Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Organ Morphogenesis Cytokine-mediated Signaling Pathway Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Osteoclast Development	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Lipopolysaccharide Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Response To Drug Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Spleen Development Cell Motility PMA-inducible Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cellular Component Movement Response To High Density Lipoprotein Particle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Hedgehog ligand biogenesis TNF signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Death Receptor Signalling Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Release of Hh-Np from the secreting cell Signaling by NOTCH1 Programmed Cell Death Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Regulated proteolysis of p75NTR Signalling by NGF Collagen degradation Signaling by NOTCH Processing-defective Hh variants abrogate ligand secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 Signaling by EGFR in Cancer Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Extrinsic Pathway Growth hormone receptor signaling
Drugs
Diseases
GWAS		Bone mineral density ( 23437003) Cortical thickness ( 22792071) Crohn's disease ( 21102463)
Protein-Protein Interactions		31 interactors: ADAM17 ADAM19 AKT1 BBS10 DDAH2 EEF1A1 EZH2 FAM213B KHDRBS1 KIAA1377 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1	14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11
Entrez ID		8600	6868
HPRD ID		04031	04703
Ensembl ID		ENSG00000120659	ENSG00000151694
Uniprot IDs		O14788 Q54A98 Q5T9Y4	B2RNB2 P78536
PDB IDs		3URF	1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Membrane Protein Proteolysis Toll-like Receptor 4 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Bacterium Membrane Protein Intracellular Domain Proteolysis Response To Molecule Of Bacterial Origin Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Transferase Activity Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Lipopolysaccharide Response To Growth Factor Response To Epidermal Growth Factor Fc Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Other Organism Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Cell Death Death Regulation Of Innate Immune Response	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gland Development Positive Regulation Of Phosphorylation Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Response To Tumor Necrosis Factor Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of APC-Cdc20 Complex Activity Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Cell Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Fever Generation Activation Of Protein Kinase Activity
Tagcloud ?		actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Difference) ?		actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Intersection) ?