TNFSF11 and TRMT2A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TNFSF11	TRMT2A
Description		TNF superfamily member 11	tRNA methyltransferase 2A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane	Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Receptor Ligand Activity	Nucleic Acid Binding RNA Binding Protein Binding Methyltransferase Activity C-methyltransferase Activity RNA Methyltransferase Activity Transferase Activity TRNA (uracil(54)-C5)-methyltransferase Activity, S-adenosyl Methionine-dependent
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Cell Communication Cell Surface Receptor Signaling Pathway JNK Cascade Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Differentiation Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tooth Eruption Bone Resorption Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Bone Development Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	RNA Processing MRNA Processing TRNA Processing Methylation
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Arthritis (juvenile idiopathic) ( 33106285) Asthma (childhood onset) ( 30929738) Bone mineral density ( 23437003 24249740) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 33547301 29403010) Vitiligo ( 27723757)
Interacting Genes		32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1	22 interacting genes: AIMP2 ANXA7 APP APPBP2 ATP1B1 CDK4 CDKN1A GADD45G MCC MEOX2 MESD PICK1 PIK3R3 PIN1 RASA1 RCC1 SMN1 TK1 TLE5 TNFSF11 UBC ZNF837
Entrez ID		8600	27037
HPRD ID		04031	13719
Ensembl ID		ENSG00000120659	ENSG00000099899
Uniprot IDs		O14788 Q54A98 Q5T9Y4	F2Z2W7 Q8IZ69
PDB IDs		3URF 5BNQ	7NTN 7NTO
Enriched GO Terms of Interacting Partners?		Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Response To Tumor Necrosis Factor Response To Lipid Membrane Protein Proteolysis Endopeptidase Activity Metalloendopeptidase Activity Cellular Response To Tumor Necrosis Factor Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Catalytic Activity Response To UV-A Response To DsRNA Response To Epidermal Growth Factor MAP Kinase Activity Metallopeptidase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Regulation Of Lipid Transport Epidermal Growth Factor Receptor Signaling Pathway Response To Amino Acid Starvation Cytokine-mediated Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Cholesterol Biosynthetic Process Membrane Protein Ectodomain Proteolysis I-kappaB/NF-kappaB Complex Interleukin-34-mediated Signaling Pathway Stress-activated MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Stress Stress-activated Protein Kinase Signaling Cascade Regulation Of Steroid Biosynthetic Process Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Defense Response Protein Metabolic Process Regulation Of Golgi Inheritance Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Cholesterol Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Response To Mechanical Stimulus Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process	Regulation Of Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Anoikis Positive Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Response To Phorbol 13-acetate 12-myristate Cytoplasm Low-density Lipoprotein Particle Receptor Binding Intracellular Signaling Cassette Positive Regulation Of JNK Cascade Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Regulation Of Mitotic Cell Cycle Positive Regulation Of Receptor Internalization Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle
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