KNSTRN and MAPRE1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, two hybrid, proximity labelling technology, affinity chromatography technology)

		KNSTRN	MAPRE1
Description		kinetochore localized astrin (SPAG5) binding protein	microtubule associated protein RP/EB family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Ruffle Nucleus Chromosome Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Astral Microtubule End Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding	RNA Binding Protein Binding Microtubule Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Intracellular Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Non-motile Cilium Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MECOM MPHOSPH6 NUPR1 OIP5 PALS2 PPL WASHC3 ZDHHC17	50 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653
Entrez ID		90417	22919
HPRD ID		12669	04379
Ensembl ID		ENSG00000128944	ENSG00000101367
Uniprot IDs		Q9Y448	Q15691
PDB IDs			1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Astral Microtubule End Regulation Of Organelle Organization Regulation Of Supramolecular Fiber Organization Intracellular Protein Localization Cellular Component Assembly Regulation Of Cytoskeleton Organization Protein Localization To Microtubule Microtubule Plus-end Binding Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Binding Microtubule Plus-end Cytoskeleton Spindle Midzone Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Transport Regulation Of Actin Nucleation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Perinuclear Endoplasmic Reticulum Lumen Establishment Of Protein Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cell Division Protein Localization To Astral Microtubule Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Autophagosome Assembly Protein Localization To Cytoskeleton Regulation Of Dendritic Spine Development Positive Regulation Of Cellular Component Biogenesis Cornified Envelope Cytoplasmic Microtubule Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein-containing Complex Organization Septin Cytoskeleton Actin Polymerization Or Depolymerization Zonula Adherens Assembly Protein Localization To Mitotic Spindle Regulation Of Microtubule Polymerization Protein Localization To Spindle Microtubule Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Vacuole Organization Regulation Of Organelle Assembly Opsin Transport Intraciliary Transport Particle	Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Cytoskeleton Organization Regulation Of Cell Cycle Microtubule-based Process Establishment Of Mitotic Spindle Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoplasm Microtubule Cytoskeleton Regulation Of Organelle Organization Establishment Of Organelle Localization Organelle Localization Mitotic Spindle Microtubule Plus-end Positive Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Establishment Of Spindle Localization Kinetochore Spindle Localization Centrosome Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Microtubule Binding Cellular Component Assembly Regulation Of Microtubule Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Cytosol Establishment Of Localization In Cell Establishment Of Spindle Orientation Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Metabolic Process Microtubule Plus-end Binding Spindle Perinuclear Region Of Cytoplasm Protein Kinase Binding Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Macromolecule Metabolic Process
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