KNSTRN and ZDHHC17

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		KNSTRN	ZDHHC17
Description		kinetochore localized astrin (SPAG5) binding protein	zDHHC palmitoyltransferase 17
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Ruffle Nucleus Chromosome Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)
Interacting Genes		17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MECOM MPHOSPH6 NUPR1 OIP5 PALS2 PPL WASHC3 ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		90417	23390
HPRD ID		12669	09697
Ensembl ID		ENSG00000128944	ENSG00000186908
Uniprot IDs		Q9Y448	A8KA01 Q8IUH5
PDB IDs			3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Astral Microtubule End Regulation Of Organelle Organization Regulation Of Supramolecular Fiber Organization Intracellular Protein Localization Cellular Component Assembly Regulation Of Cytoskeleton Organization Protein Localization To Microtubule Microtubule Plus-end Binding Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Binding Microtubule Plus-end Cytoskeleton Spindle Midzone Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Transport Regulation Of Actin Nucleation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Perinuclear Endoplasmic Reticulum Lumen Establishment Of Protein Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cell Division Protein Localization To Astral Microtubule Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Autophagosome Assembly Protein Localization To Cytoskeleton Regulation Of Dendritic Spine Development Positive Regulation Of Cellular Component Biogenesis Cornified Envelope Cytoplasmic Microtubule Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein-containing Complex Organization Septin Cytoskeleton Actin Polymerization Or Depolymerization Zonula Adherens Assembly Protein Localization To Mitotic Spindle Regulation Of Microtubule Polymerization Protein Localization To Spindle Microtubule Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Vacuole Organization Regulation Of Organelle Assembly Opsin Transport Intraciliary Transport Particle	Protein Binding
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