KNSTRN and MPP6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		KNSTRN	MPP6
Gene Name		kinetochore-localized astrin/SPAG5 binding protein	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Cytoplasm Microtubule Cytoskeleton Microtubule Plus-end Mitotic Spindle	Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding PDZ Domain Binding
	Biological Process	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Protein Complex Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CHMP1B CLU MAPK6 MPHOSPH6 MPP6 NUPR1 ZDHHC17	28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1
Entrez ID		90417	51678
HPRD ID		12669	09509
Ensembl ID		ENSG00000128944	ENSG00000105926
Uniprot IDs		Q9Y448	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly RRNA Processing RRNA Metabolic Process Central Nervous System Myelin Maintenance Intrinsic Apoptotic Signaling Pathway Ribosome Biogenesis Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Positive Regulation Of Beta-amyloid Formation Regulation Of Mitotic Spindle Assembly Protein Complex Assembly Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Regulation Of Spindle Assembly Regulation Of Female Gonad Development Ribonucleoprotein Complex Biogenesis Regulation Of Protein Complex Assembly Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Regulation Of Mitotic Spindle Organization Negative Regulation Of Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Glial Cell Proliferation Response To Misfolded Protein Regulation Of Beta-amyloid Formation Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Cell Separation After Cytokinesis Central Nervous System Myelination Lipoprotein Transport Protein Transport Magnesium Ion Transport Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage NcRNA Metabolic Process Mitotic Metaphase Plate Congression Regulation Of Protein Oligomerization Protein Palmitoylation Macrophage Activation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Release Of Cytochrome C From Mitochondria Metaphase Plate Congression Myelin Maintenance	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		aneuploidy carcinomas chromatid cohesion concentrated correlate cutaneous discovery disrupt encodes encoding enhance hotspot kinetochore mutagenesis mutations notably occur precursors recurrent report scc sccs ser24phe signature squamous tumorigenesis tumors ultraviolet	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Difference) ?		aneuploidy carcinomas chromatid cohesion concentrated correlate cutaneous discovery disrupt encodes encoding enhance hotspot kinetochore mutagenesis mutations notably occur precursors recurrent report scc sccs ser24phe signature squamous tumorigenesis tumors ultraviolet	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Intersection) ?