KNSTRN and OIP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KNSTRN	OIP5
Description		kinetochore localized astrin (SPAG5) binding protein	Opa interacting protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Ruffle Nucleus Chromosome Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Chromocenter Cajal Body Nuclear Speck CENP-A Recruiting Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus	Chromosome Segregation Cell Communication CENP-A Containing Chromatin Assembly Cell Division Pericentric Heterochromatin Organization
Pathways			Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 28067908)
Interacting Genes		17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MECOM MPHOSPH6 NUPR1 OIP5 PALS2 PPL WASHC3 ZDHHC17	142 interacting genes: A1CF ABI2 ABI3 ABL2 AGXT BCAS2 BEX2 BFSP2 BLOC1S5 BRAF C1orf94 C21orf91 C7orf57 CASP10 CBY2 CCDC22 CCDC24 CCHCR1 CDR2L CEP57 CERK CHCHD2 CIMIP1 COX5B CRACR2A CTNNA3 DMRT3 DTNBP1 DTX2 DUSP21 EFHC1 EIF4ENIF1 ESS2 FAM161B FAM222B FOXJ1 FSD2 GADD45GIP1 GCC1 GEM GLIS2 GPANK1 GPS2 HAPLN2 HGS HJURP HOXB5 HOXB9 HOXC8 HSF4 IL16 KANK2 KDM1A KIF9 KLHL38 KLHL42 KNSTRN KRT14 KRT15 KRT27 KRT3 KRT35 KRT37 KRT40 KRT6B KRT75 KRT81 KRT83 KRT86 KRTAP13-2 KRTAP19-5 KRTAP19-6 LENG1 MECOM MED4 MEIS2 MGAT5B MIIP MIS18A MIS18BP1 MISP MORN3 MYEF2 MYRIP NDUFAB1 NECAB2 NUP54 NUP62 P4HA3 PATZ1 PEX19 PHETA1 PITX2 PLAGL2 POLR2J POU6F2 PRR35 PSMB1 RAB26 RABGEF1 RAF1 RARG RIBC1 RUNX1T1 RUSC1 S100Z SAMD7 SAXO1 SAXO4 SHISA6 SKIL SMARCE1 SNRNP25 SNRPB SOHLH1 SORBS3 SPATA24 SPMIP4 SYCE1L TEKT3 TEX12 TFAP2D TFIP11 TIMM8A TLX3 TMPO TPM3 TPRX1 TRIB3 TRIM73 TRIP6 TROAP TSSK3 USHBP1 USP2 USP54 WASHC1 YTHDF1 ZIC1 ZMAT1 ZNF417 ZNF655
Entrez ID		90417	11339
HPRD ID		12669	09352
Ensembl ID		ENSG00000128944	ENSG00000104147
Uniprot IDs		Q9Y448	O43482
PDB IDs			7SFY
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Astral Microtubule End Regulation Of Organelle Organization Regulation Of Supramolecular Fiber Organization Intracellular Protein Localization Cellular Component Assembly Regulation Of Cytoskeleton Organization Protein Localization To Microtubule Microtubule Plus-end Binding Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Binding Microtubule Plus-end Cytoskeleton Spindle Midzone Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Transport Regulation Of Actin Nucleation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Perinuclear Endoplasmic Reticulum Lumen Establishment Of Protein Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cell Division Protein Localization To Astral Microtubule Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Autophagosome Assembly Protein Localization To Cytoskeleton Regulation Of Dendritic Spine Development Positive Regulation Of Cellular Component Biogenesis Cornified Envelope Cytoplasmic Microtubule Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein-containing Complex Organization Septin Cytoskeleton Actin Polymerization Or Depolymerization Zonula Adherens Assembly Protein Localization To Mitotic Spindle Regulation Of Microtubule Polymerization Protein Localization To Spindle Microtubule Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Vacuole Organization Regulation Of Organelle Assembly Opsin Transport Intraciliary Transport Particle	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Keratin Filament Protein Binding Supramolecular Fiber Organization Cytoskeleton Axonemal A Tubule Inner Sheath Cytoskeleton Organization Structural Molecule Activity Organelle Organization Sperm Flagellum Keratinization Motile Cilium CENP-A Containing Chromatin Assembly Pericentric Heterochromatin Organization CENP-A Recruiting Complex
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