PLXNB1 and SEMA4B

Number of citations of the paper that reports this interaction (PubMedID 12123608)
0

Data Source:
HPRD (in vitro, in vivo)

		PLXNB1	SEMA4B
Description		plexin B1	semaphorin 4B
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Postsynaptic Membrane Glutamatergic Synapse	Plasma Membrane Membrane Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Semaphorin-plexin Signaling Pathway Inhibitory Synapse Assembly	Neural Crest Cell Migration Nervous System Development Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Acne (severe) ( 30542056) Frontal fibrosing alopecia ( 30850646) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Pulse pressure ( 27841878) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		15 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MECOM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	4 interacting genes: CPEB2 DLG4 GIPC1 PLXNB1
Entrez ID		5364	10509
HPRD ID		03032	10217
Ensembl ID		ENSG00000164050	ENSG00000185033
Uniprot IDs		O43157	Q9NPR2
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W 7VF3 7VG7 8B3K
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Chemotaxis Locomotion Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neuron Projection Development Neural Crest Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Mesenchymal Cell Migration Anatomical Structure Arrangement Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Rho Protein Signal Transduction Motor Neuron Axon Guidance Cellular Developmental Process Ventral Trunk Neural Crest Cell Migration Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Ameboidal-type Cell Migration Trigeminal Ganglion Development Cell Migration Positive Regulation Of Cell Migration Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Negative Chemotaxis Neuron Migration Positive Regulation Of Locomotion Cranial Ganglion Development Trunk Neural Crest Cell Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Migration Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Regulation Of Cell Motility Regulation Of Actin Filament-based Process Cell Motility Regulation Of Locomotion	Cerebellar Mossy Fiber Synaptic Vesicle Juxtaparanode Region Of Axon Synaptic Vesicle Maturation P2Y1 Nucleotide Receptor Binding Regulation Of Synaptic Plasticity Locomotory Exploration Behavior Cell Projection Morphogenesis Positive Regulation Of Signal Transduction Neuron Spine Cellular Response To Potassium Ion Positive Regulation Of Neuron Projection Arborization AMPA Glutamate Receptor Clustering Regulation Of Neuron Projection Arborization Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Regulation Of Grooming Behavior NMDA Selective Glutamate Receptor Signaling Pathway Dendritic Spine Neuron Projection Morphogenesis Acetylcholine Receptor Binding Neuron Projection Glutamatergic Synapse Neurotransmitter-gated Ion Channel Clustering Trans-synaptic Signaling Positive Regulation Of Cell Projection Organization Synaptic Signaling Chemical Synaptic Transmission Regulation Of Cell Morphogenesis Neuroligin Family Protein Binding Postsynaptic Membrane Semaphorin Receptor Activity GTPase Activating Protein Binding Negative Regulation Of Osteoblast Proliferation Ossification Involved In Bone Maturation Semaphorin Receptor Complex Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion GTPase Inhibitor Activity Negative Regulation Of Cytoplasmic Translation Negative Regulation Of Translational Elongation Ribosomal Large Subunit Binding Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Receptor Internalization MRNA Regulatory Element Binding Translation Repressor Activity Response To Potassium Ion
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