PLXNB1 and RND3

Number of citations of the paper that reports this interaction (PMID 12730235)
30

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PLXNB1	RND3
Gene Name		plexin B1	Rho family GTPase 3
Image
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Intracellular Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Positive Regulation Of Rho GTPase Activity Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis	Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Actin Cytoskeleton Organization
Pathways		Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Endometriosis ( 23472165) Type 2 diabetes ( 22238593)
Protein-Protein Interactions		10 interactors: ARHGEF11 ARHGEF12 KMT2A MET PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D	7 interactors: ARHGAP5 CIT PLXNB1 ROCK1 SKP2 UBC UBXN11
Entrez ID		5364	390
HPRD ID		03032	04233
Ensembl ID		ENSG00000164050	ENSG00000115963
Uniprot IDs		O43157	B2R838 P61587
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA	1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Semaphorin-plexin Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Cell Development Response To External Stimulus Small GTPase Mediated Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Regulation Of Rho Protein Signal Transduction Anatomical Structure Morphogenesis Developmental Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Migration Actin Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Neurotrophin Signaling Pathway Actin Filament-based Process Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Locomotion Regulation Of Cellular Component Movement Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity Epithelial Cell Morphogenesis	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Proteolysis Cellular Response To Cell-matrix Adhesion Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Mitotic Cell Cycle Protein Polyubiquitination Cell Communication Neuron Projection Development Membrane To Membrane Docking Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Apical Constriction Ras Protein Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Cell Cycle Process Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Bleb Assembly Cellular Protein Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Viral Protein Processing Neuron Differentiation Cell Projection Organization Negative Regulation Of Osteoblast Proliferation Myoblast Migration Regulation Of Cellular Component Size
Tagcloud ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby	128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability
Tagcloud (Difference) ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby	128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability
Tagcloud (Intersection) ?