PLXNB1 and ARHGEF11

Number of citations of the paper that reports this interaction (PMID 12183458)
53

Data Source:
HPRD (two hybrid)

		PLXNB1	ARHGEF11
Gene Name		plexin B1	Rho guanine nucleotide exchange factor (GEF) 11
Image
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Intracellular Plasma Membrane Integral Component Of Plasma Membrane	Intracellular Cytoplasm Cytosol Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Positive Regulation Of Rho GTPase Activity Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis	Cytokinesis Regulation Of Cell Growth Movement Of Cell Or Subcellular Component Striated Muscle Contraction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Signaling by GPCR Signalling by NGF Axon guidance Semaphorin interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ARHGEF11 ARHGEF12 KMT2A MET PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D	13 interactors: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 RHOA SLC1A6
Entrez ID		5364	9826
HPRD ID		03032	09302
Ensembl ID		ENSG00000164050	ENSG00000132694
Uniprot IDs		O43157	F8W8P9 O15085
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA	1HTJ 1XCG 2DLS 3KZ1 3T06
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Semaphorin-plexin Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Cell Development Response To External Stimulus Small GTPase Mediated Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Regulation Of Rho Protein Signal Transduction Anatomical Structure Morphogenesis Developmental Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Migration Actin Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Neurotrophin Signaling Pathway Actin Filament-based Process Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Locomotion Regulation Of Cellular Component Movement Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity Epithelial Cell Morphogenesis	Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Neuron Differentiation Regulation Of Rho Protein Signal Transduction Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Movement Regulation Of Neuron Projection Development Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Rho Protein Signal Transduction Axonogenesis Generation Of Neurons Signaling Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Cell Communication Axon Development Positive Regulation Of Phospholipase Activity Anatomical Structure Morphogenesis Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Ras Protein Signal Transduction Regulation Of Neurogenesis Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Ossification Involved In Bone Maturation Signal Transduction Positive Regulation Of Intracellular Signal Transduction Bone Maturation
Tagcloud ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby
Tagcloud (Difference) ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby
Tagcloud (Intersection) ?